2. Metabolic Enzyme/Protease
  3. Carbonic Anhydrase
  4. hCAIX-IN-8

hCAIX-IN-8 (compound 7i) 是一种有效的选择性 hCAIX 抑制剂，CAII、CAIX、CAVA 的IC50s 分别为 1.99, 0.024, 1.10 µM。hCAIX-IN-8 具有低毒性的抗增殖活性。hCAIX-IN-8 减少上皮细胞向间充质细胞的转化并诱导细胞凋亡 (apoptosis)。hCAIX-IN-8 抑制细胞迁移和定植。

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hCAIX-IN-8 Chemical Structure

hCAIX-IN-8 Chemical Structure

CAS No. : 2414633-40-0

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hCAIX-IN-8 相关抗体

Top Publications Citing Use of Products

查看 Carbonic Anhydrase 亚型特异性产品:

查看所有亚型
CA CA I CA Ⅱ CA Ⅸ CA XII

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

hCAIX-IN-8 (compound 7i) is a potent and selective hCAIX inhibitor with IC50s of 1.99, 0.024, 1.10 µM for CAII, CAIX, CAVA respectively. hCAIX-IN-8 shows anti-proliferation activity with low toxicity. hCAIX-IN-8 decreases the epithelial to mesenchymal transitions and induces apoptosis. hCAIX-IN-8 inhibits cell migration and colonization potential[1].

IC50 & Target

IC50: 1.99 µM (CAII); 0.024 (CAIX), 1.10 µM (CAVA)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HepG2 IC50
11.22 μM
Compound: 7i
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 32209296]
HT-29 IC50
8.44 μM
Compound: 7i
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 32209296]
体外研究
(In Vitro)

hCAIX-IN-8 (compound 7i) shows anti-proliferation activity with IC50是of 8.44, 11.22 µM for HT29, HepG2 cells, respectively[1].
hCAIX-IN-8 induces apoptosis in 24.44% and 19.22% of HT29 and HepG2 cells, respectivelysup>[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

hCAIX-IN-8 相关抗体:
分子量

396.35

Formula

C19H16N4O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

hCAIX-IN-8 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hCAIX-IN-82414633-40-0Carbonic AnhydraseCarbonate dehydrataselow toxicityHEK293apoptosisHT29HepG2 cellsmigrationanti-proliferationInhibitorinhibitorinhibit

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