2. Anti-infection
  3. HIV
  4. HIV-1 inhibitor-30

HIV-1 inhibitor-30 (compound 10i) 是一种有效的 HIV-1 抑制剂，对 HIV-1 的 EC50 为 40 nM，对 HIV-1 RT DNA聚合酶的 IC50 为 80 nM。HIV-1 inhibitor-30 对 7 种非核苷逆转录酶抑制剂 (NNRTI) 耐药的 HIV-1 菌株 (RT-K103N; RT-Y181C; RT-K103N,Y181C; RT-L100I,K103N; RT-Y188L; RT-K103N,G190A; RT-K103N,V108I) 具有较高的抗逆转录病毒活性，IC50 为 0.04~1.42 μM。

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HIV-1 inhibitor-30 Chemical Structure

HIV-1 inhibitor-30 Chemical Structure

CAS No. : 2132412-77-0

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HIV-1 inhibitor-30 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

HIV-1 inhibitor-30 (compound 10i) is a potent HIV-1 inhibitor with an EC50 value of 40 nM and an IC50 value of 80 nM for HIV-1 RT DNA polymerase. HIV-1 inhibitor-30 has highly antiretroviral activity against seven non-nucleoside reverse transcriptase inhibitor (NNRTI)-resistant HIV-1 strains (RT-K103N; RT-Y181C; RT-K103N,Y181C; RT-L100I,K103N; RT-Y188L; RT-K103N,G190A; RT-K103N,V108I) with IC50s of 0.04~1.42 μM. HIV-1 inhibitor-30 can be used for researching AIDS[1].

IC50 & Target

EC50: 40 nM (HIV-1 WT)[1]
IC50: 80 nM (HIV-1 RT DNA polymerase)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK-293T CC50
22.06 μM
Compound: 10i
Cytotoxicity against human HEK 293T cells assessed as reduction in cell viability measured after 48 hrs by Celltiter-glo assay
Cytotoxicity against human HEK 293T cells assessed as reduction in cell viability measured after 48 hrs by Celltiter-glo assay
[PMID: 32004936]
分子量

357.83

Formula

C19H20ClN3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HIV-1 inhibitor-30 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HIV-1 inhibitor-302132412-77-0HIVHuman immunodeficiency virusAntiretroviralNNRTI-resistantRT DNA polymeraseAIDSInhibitorinhibitorinhibit

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HY-146365
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