HIV gp120 (318-327) 

HIV gp120 (318-327) is a short sequence of the HIV-1 strain IIIB envelope peptide (rgpgrafvti) that corresponds to the conserved C-terminal region of the glycoprotein. HIV gp120 (318-327) is part of the HIV vaccine V3 peptide epitope, also known as the I10 peptide. However, HIV gp120 (318-327) lacks the A2 anchor residues recognized by epitope-specific CTLs but has structural features that confer promiscuous A2 binding^[1][2].

HIV gp120 (318-327) (0.5 μM) 刺激表达 7DV3 突变体的 JA2 细胞中 CTL 反应减弱^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1073.25

C₄₈H₈₀N₁₆O₁₂

147841-68-7

Arg-Gly-Pro-Gly-Arg-Ala-Phe-Val-Thr-Ile

RGPGRAFVTI

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kmieciak D, et al. The effect of deletion of the V3 loop of gp120 on cytotoxic T cell responses and HIV gp120-mediated pathogenesis. J Immunol. 1998 Jun 1;160(11):5676-83.  [Content Brief]

  [2]. Gu L, et al. A recombinant adenovirus-based vector elicits a specific humoral immune response against the V3 loop of HIV-1 gp120 in mice through the "Antigen Capsid-Incorporation" strategy. Virol J. 2014 Jun 16;11:112.  [Content Brief]