2. Metabolic Enzyme/Protease
  3. Indoleamine 2,3-Dioxygenase (IDO)
  4. IDO1-IN-7

IDO1-IN-7 是一种高效、选择性的 IDO1 抑制剂，在细胞中对 IDO1 作用的 IC50 值为 6.1 nM。 IDO1-IN-7 具有免疫调节作用，用于癌症的研究。

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IDO1-IN-7 Chemical Structure

IDO1-IN-7 Chemical Structure

CAS No. : 2351199-98-7

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IDO1-IN-7 相关抗体

Top Publications Citing Use of Products

查看 Indoleamine 2,3-Dioxygenase (IDO) 亚型特异性产品:

查看所有亚型
IDO1 IDO2 IDO

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IDO1-IN-7 is a highly potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, with an IC50 of 6.1 nM in in the cellular assay (SKOV3). IDO1-IN-7 has immunomodulatory effects. IDO1-IN-7 can be used for the research of cancer[1].

IC50 & Target

IC50: 6.1 nM (IDO1, SKOV3 cells)[1]
体外研究
(In Vitro)

IDO1-IN-7 exhibits moderate potency in a human whole blood assay with an IC50of 330 nM[1].
IDO1-IN-7 shows a favorable profile such as good metabolic stability and acceptable off-target selectivity[1].
IDO1-IN-7 shows a high selectivity for IDO1 over tryptophan 2,3-dioxygenase (TDO) (IC50=14,000 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IDO1-IN-7 相关抗体:
体内研究
(In Vivo)

IDO1-IN-7 (10 mg/kg; p.o.) shows Cmax=10.0 µM, AUC0-8 h=27.1 µM*h, t1/2=1.4 h in mouse[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse[1]
Dosage: 10 mg/kg (Pharmacokinetic Analysis)
Administration: Oral administration
Result: Cmax (10.0 µM), AUC0-8 h (27.1 µM*h), t1/2 (1.4 h)
分子量

427.86

Formula

C22H19ClFN3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IDO1-IN-7 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IDO1-IN-72351199-98-7Indoleamine 2,3-Dioxygenase (IDO)indoleamine-2,3-dioxygenase-1IDO1checkpointimmunomodulatinganti-tumorInhibitorinhibitorinhibit

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产品名称：
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目录号：
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