2. Immunology/Inflammation Cell Cycle/DNA Damage Apoptosis NF-κB
  3. NO Synthase Topoisomerase Apoptosis NF-κB
  4. iNOS/TopoI-IN-1

iNOS/TopoI-IN-1 (compound AuL9) 是一种多靶点杂交分子，具有抗肿瘤，抗炎和抗氧化活性。iNOS/TopoI-IN-1 在体外抑制乳腺癌细胞 MCF-7 和 MDA MB-231 的生长，IC50 值分别为 3.5 μM 和 6.3 μM，并通过抑制人类拓扑异构酶I (TopoI) (Ki=2.72 μM) 引发 DNA 损伤并诱导乳腺癌细胞凋亡 (apoptosis)。此外，NOS/TopoI-IN-1 通过抑制了 NF-kB 的活化，来抑制 iNOS 的表达 (Ki=1.49 μM)。

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iNOS/TopoI-IN-1 Chemical Structure

iNOS/TopoI-IN-1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

iNOS/TopoI-IN-1 相关抗体

Top Publications Citing Use of Products

查看 NO Synthase 亚型特异性产品:

查看所有亚型
nNOS iNOS eNOS

查看 Topoisomerase 亚型特异性产品:

查看所有亚型
Topoisomerase Topo I Topo II

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

iNOS/TopoI-IN-1 (compound AuL9) is a multi-target hybrid molecule with anti-tumor, anti-inflammatory and antioxidant activities. iNOS/TopoI-IN-1 inhibits the growth of breast cancer cells MCF-7 and MDA MB-231 in vitro with IC50 of 3.5 μM and 6.3 μM, respectively, and induces DNA damage and apoptosis of breast cancer cells by inhibiting human topoisomerase I (TopoI) (Ki=2.72 μM). In addition, NOS/TopoI-IN-1 inhibits the expression of iNOS by inhibiting the activation of NF-kB (Ki=1.49 μM)[1].

IC50 & Target[1]

Topoisomerase I

2.72 μM (Ki)

iNOS

1.49 μM (Ki)

分子量

886.54

Formula

C34H40AuBrCl2N3OS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

iNOS/TopoI-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

iNOS/TopoI-IN-1NO SynthaseTopoisomeraseApoptosisNF-κBNitric oxide synthasesNOSNuclear factor-κBNuclear factor-kappaBAnti-tumoranti-inflammatoryantioxidantMCF-7MDA MB-231apoptosistopoisomerase IInhibitorinhibitorinhibit

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