JS-K

目录号: HY-126193 纯度: 99.59%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

JS-K 是一种 NO 供体，在生理 pH 下与谷胱甘肽反应生成 NO。JS-K 抑制 Jurkat T 急性淋巴白血病细胞的增殖，诱导其凋亡并扰乱其细胞周期。

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JS-K Chemical Structure

CAS No. : 205432-12-8

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1 mg	￥1350	In-stock
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nNOS iNOS eNOS

生物活性
纯度 & 产品资料
参考文献

生物活性

JS-K is a NO donor that reacts with glutathione to generate NO at physiological pH^[1]. JS-K inhibits proliferation, induces apoptosis, and disrupts the cell cycle of Jurkat T acute lymphoblastic leukemia cells^[2].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
786-0	IC₅₀	0.8 μM Compound: JS-K	Antiproliferative activity against human 786O cells after 72 hrs by MTT assay Antiproliferative activity against human 786O cells after 72 hrs by MTT assay	[PMID: 18930407]
A2780	IC₅₀	0.63 μM Compound: 19	Antiproliferative activity against human A2780 cells after 48 hrs by MTT assay Antiproliferative activity against human A2780 cells after 48 hrs by MTT assay	[PMID: 25350923]
A549	IC₅₀	0.69 μM Compound: 6; JS-K	Antiproliferative activity against human A549 cells harboring KRAS G12S mutant assessed as inhibition of cell viability after 96 hrs by Celltiter-Glo assay Antiproliferative activity against human A549 cells harboring KRAS G12S mutant assessed as inhibition of cell viability after 96 hrs by Celltiter-Glo assay	[PMID: 32305784]
A549	IC₅₀	1.26 μM Compound: 19	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 25350923]
A549	IC₅₀	1.5 μM Compound: JS-K	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 18930407]
A549	IC₅₀	2.11 μM Compound: JS-K	Anticancer activity against human A549 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay Anticancer activity against human A549 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay	[PMID: 32156499]
A549	IC₅₀	2.313 μM Compound: JS-K	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 29501947]
A549	IC₅₀	6.53 μM Compound: JS-K	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay relative to control Antiproliferative activity against human A549 cells after 48 hrs by MTT assay relative to control	[PMID: 29220794]
A549/TR	IC₅₀	1.987 μM Compound: JS-K	Antiproliferative activity against human A549/TR cells after 72 hrs by MTT assay Antiproliferative activity against human A549/TR cells after 72 hrs by MTT assay	[PMID: 29501947]
B16	IC₅₀	1340 nM Compound: 1; JS-K	Antiproliferative activity against mouse B16 cells after 72 hrs by MTT assay Antiproliferative activity against mouse B16 cells after 72 hrs by MTT assay	[PMID: 29420887]
Bel-7402	IC₅₀	5.17 μM Compound: JS-K	Cytotoxicity against human Bel7402 cells after 72 hrs by MTT assay Cytotoxicity against human Bel7402 cells after 72 hrs by MTT assay	[PMID: 23617697]
BT-474	IC₅₀	3.66 μM Compound: JS-K	Anticancer activity against human BT474 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay Anticancer activity against human BT474 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay	[PMID: 32156499]
Caco-2	IC₅₀	2.6 μM Compound: JS-K	Antiproliferative activity against human Caco-2 cells after 72 hrs by MTT assay Antiproliferative activity against human Caco-2 cells after 72 hrs by MTT assay	[PMID: 18930407]
CCRF-CEM	IC₅₀	0.89 μM Compound: JS-K	Anticancer activity against human CCRF-CEM cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay Anticancer activity against human CCRF-CEM cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay	[PMID: 32156499]
HCT-116	IC₅₀	0.5 μM Compound: 6; JS-K	Antiproliferative activity against human HCT116 cells harboring KRAS G13D mutant assessed as inhibition of cell viability after 96 hrs by Celltiter-Glo assay Antiproliferative activity against human HCT116 cells harboring KRAS G13D mutant assessed as inhibition of cell viability after 96 hrs by Celltiter-Glo assay	[PMID: 32305784]
HCT-116	IC₅₀	0.7 μM Compound: JS-K	Antiproliferative activity against human HCT 116 cells after 72 hrs by MTT assay Antiproliferative activity against human HCT 116 cells after 72 hrs by MTT assay	[PMID: 18930407]
HCT-116	IC₅₀	3.75 μM Compound: JS-K	Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	10.1039/C5MD00158G
HCT-116	IC₅₀	4.86 μM Compound: JS-K	Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay relative to control Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay relative to control	[PMID: 29220794]
HCT-15	IC₅₀	0.6 μM Compound: JS-K	Antiproliferative activity against human HCT-15 cells after 72 hrs by MTT assay Antiproliferative activity against human HCT-15 cells after 72 hrs by MTT assay	[PMID: 18930407]
HeLa	IC₅₀	3.56 μM Compound: 19	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 25350923]
HepG2	IC₅₀	12.2 μM Compound: JS-K	Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay	[PMID: 23617697]
HepG2	IC₅₀	5.19 μM Compound: JS-K	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 23617697]
HepG2	IC₅₀	7.12 μM Compound: JS-K	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 23617697]
HepG2	IC₅₀	7.42 μM Compound: JS-K	Cytotoxicity against human HepG2 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	10.1039/C5MD00158G
HL-60	IC₅₀	0.2 μM Compound: JS-K	Antiproliferative activity against human HL60 cells assessed as decrease in cell viability measured after 3 days by MTT assay Antiproliferative activity against human HL60 cells assessed as decrease in cell viability measured after 3 days by MTT assay	[PMID: 28505442]
HL-60	IC₅₀	0.2 μM Compound: JS-K	Antiproliferative activity against human HL-60 cells after 72 hrs by MTT assay Antiproliferative activity against human HL-60 cells after 72 hrs by MTT assay	[PMID: 18930407]
HL-60	IC₅₀	0.2 μM Compound: JS-K	Antiproliferative activity against human HL60 cells after 24 hrs Antiproliferative activity against human HL60 cells after 24 hrs	[PMID: 19364650]
HL-60	IC₅₀	0.53 μM Compound: 6; JS-K	Antiproliferative activity against human HL60 cells harboring NRAS K61L mutant assessed as inhibition of cell viability after 96 hrs by Celltiter-Glo assay Antiproliferative activity against human HL60 cells harboring NRAS K61L mutant assessed as inhibition of cell viability after 96 hrs by Celltiter-Glo assay	[PMID: 32305784]
HT-29	IC₅₀	0.8 μM Compound: JS-K	Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay	[PMID: 18930407]
hTERT-BJ	IC₅₀	10 μM Compound: JS-K	Antiproliferative activity against human BJ-5ta cells after 72 hrs by MTT assay Antiproliferative activity against human BJ-5ta cells after 72 hrs by MTT assay	[PMID: 18930407]
HUVEC	IC₅₀	5.39 μM Compound: 19	Antiproliferative activity against HUVEC after 48 hrs by MTT assay Antiproliferative activity against HUVEC after 48 hrs by MTT assay	[PMID: 25350923]
Jurkat E6.1	IC₅₀	0.92 μM Compound: JS-K	Anticancer activity against human Jurkat E6-1 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay Anticancer activity against human Jurkat E6-1 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay	[PMID: 32156499]
L02	IC₅₀	1.99 μM Compound: 6; JS-K	Cytotoxicity against human HL7702 cells assessed as reduction in cell viability after 96 hrs by Celltiter-Glo assay Cytotoxicity against human HL7702 cells assessed as reduction in cell viability after 96 hrs by Celltiter-Glo assay	[PMID: 32305784]
MCF-10A	IC₅₀	4.91 μM Compound: JS-K	Antiproliferative activity against human MCF10A cells after 48 hrs by MTT assay relative to control Antiproliferative activity against human MCF10A cells after 48 hrs by MTT assay relative to control	[PMID: 29220794]
MCF7	IC₅₀	993 nM Compound: 1; JS-K	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 29420887]
MDA-MB-231	IC₅₀	2.9 μM Compound: 6; JS-K	Antiproliferative activity against human MDA-MB-231 cells harboring KRAS G13D/BRAF G464V mutant assessed as inhibition of cell viability after 96 hrs by Celltiter-Glo assay Antiproliferative activity against human MDA-MB-231 cells harboring KRAS G13D/BRAF G464V mutant assessed as inhibition of cell viability after 96 hrs by Celltiter-Glo assay	[PMID: 32305784]
MDA-MB-231	IC₅₀	5.75 μM Compound: JS-K	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay relative to control Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay relative to control	[PMID: 29220794]
MDA-MB-231	IC₅₀	7.93 μM Compound: JS-K	Anticancer activity against human MDA-MB-231 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay Anticancer activity against human MDA-MB-231 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay	[PMID: 32156499]
NCI-H1373	IC₅₀	0.86 μM Compound: 1, JS-K	Antiproliferative activity against human NCI-H1373 cells after 72 hrs by MTT assay Antiproliferative activity against human NCI-H1373 cells after 72 hrs by MTT assay	[PMID: 22003962]
NCI-H1703	IC₅₀	0.57 μM Compound: 1, JS-K	Antiproliferative activity against human NCI-H1703 cells after 72 hrs by MTT assay Antiproliferative activity against human NCI-H1703 cells after 72 hrs by MTT assay	[PMID: 22003962]
NCI-H1703	IC₅₀	1.08 μM Compound: 1, Js-K	Antiproliferative activity against human NCI-H1703 cells after 48 hrs by MTT assay Antiproliferative activity against human NCI-H1703 cells after 48 hrs by MTT assay	[PMID: 22480849]
NCI-H1944	IC₅₀	> 10 μM Compound: 1, JS-K	Antiproliferative activity against human NCI-H1944 cells after 72 hrs by MTT assay Antiproliferative activity against human NCI-H1944 cells after 72 hrs by MTT assay	[PMID: 22003962]
NCI-H2122	IC₅₀	3.17 μM Compound: 1, JS-K	Antiproliferative activity against human NCI-H2122 cells after 72 hrs by MTT assay Antiproliferative activity against human NCI-H2122 cells after 72 hrs by MTT assay	[PMID: 22003962]
NCI-H441	IC₅₀	0.94 μM Compound: 1, JS-K	Antiproliferative activity against human NCI-H441 cells after 72 hrs by MTT assay Antiproliferative activity against human NCI-H441 cells after 72 hrs by MTT assay	[PMID: 22003962]
NCI-H441	IC₅₀	1 μM Compound: JS-K	Antiproliferative activity against human H441 cells after 72 hrs by MTT assay Antiproliferative activity against human H441 cells after 72 hrs by MTT assay	[PMID: 18930407]
NCI-H838	IC₅₀	4.3 μM Compound: JS-K	Antiproliferative activity against human H838 cells after 72 hrs by MTT assay Antiproliferative activity against human H838 cells after 72 hrs by MTT assay	[PMID: 18930407]
OVCAR-3	IC₅₀	0.8 μM Compound: JS-K	Antiproliferative activity against human OVCAR-3 cells after 72 hrs by MTT assay Antiproliferative activity against human OVCAR-3 cells after 72 hrs by MTT assay	[PMID: 18930407]
OVCAR-5	IC₅₀	1 μM Compound: JS-K	Antiproliferative activity against human OVCAR5 cells after 72 hrs by MTT assay Antiproliferative activity against human OVCAR5 cells after 72 hrs by MTT assay	[PMID: 18930407]
PC-3	IC₅₀	1.1 μM Compound: JS-K	Antiproliferative activity against human PC-3 cells after 72 hrs by MTT assay Antiproliferative activity against human PC-3 cells after 72 hrs by MTT assay	[PMID: 18930407]
SMMC-7721	IC₅₀	7.31 μM Compound: JS-K	Cytotoxicity against human SMMC7721 cells after 72 hrs by MTT assay Cytotoxicity against human SMMC7721 cells after 72 hrs by MTT assay	[PMID: 23617697]
SW-620	IC₅₀	5.16 μM Compound: JS-K	Cytotoxicity against human SW620 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Cytotoxicity against human SW620 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	10.1039/C5MD00158G
TK-10	IC₅₀	0.5 μM Compound: JS-K	Antiproliferative activity against human TK-10 cells after 72 hrs by MTT assay Antiproliferative activity against human TK-10 cells after 72 hrs by MTT assay	[PMID: 18930407]
U2OS	IC₅₀	6.27 μM Compound: JS-K	Antiproliferative activity against human U2OS cells after 48 hrs by MTT assay relative to control Antiproliferative activity against human U2OS cells after 48 hrs by MTT assay relative to control	[PMID: 29220794]
U-937	IC₅₀	0.3 μM Compound: JS-K	Antiproliferative activity against human U937 cells after 72 hrs by MTT assay Antiproliferative activity against human U937 cells after 72 hrs by MTT assay	[PMID: 18930407]
U-937	IC₅₀	0.3 μM Compound: JS-K	Antiproliferative activity against human U937 cells after 24 hrs Antiproliferative activity against human U937 cells after 24 hrs	[PMID: 19364650]
Vero	IC₅₀	1.16 μM Compound: 6; JS-K	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 96 hrs by Celltiter-Glo assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 96 hrs by Celltiter-Glo assay	[PMID: 32305784]

分子量

384.30

Formula

C₁₃H₁₆N₆O₈

CAS 号

205432-12-8

性状

固体

颜色

White to yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

细胞实验：

DMSO 中的溶解度 : 36 mg/mL (93.68 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.6021 mL	13.0107 mL	26.0213 mL
5 mM	0.5204 mL	2.6021 mL	5.2043 mL
10 mM	0.2602 mL	1.3011 mL	2.6021 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.59%

选择批次：

Data Sheet (594 KB) SDS (251 KB)

COA (283 KB) LCMS (94 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Shami PJ, et al. JS-K, a glutathione/glutathione S-transferase-activated nitric oxide donor of the diazeniumdiolate class with potent antineoplastic activity. Mol Cancer Ther. 2003 Apr;2(4):409-17. [Content Brief]

JS-K 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6021 mL	13.0107 mL	26.0213 mL	65.0533 mL
	5 mM	0.5204 mL	2.6021 mL	5.2043 mL	13.0107 mL
	10 mM	0.2602 mL	1.3011 mL	2.6021 mL	6.5053 mL
	15 mM	0.1735 mL	0.8674 mL	1.7348 mL	4.3369 mL
	20 mM	0.1301 mL	0.6505 mL	1.3011 mL	3.2527 mL
	25 mM	0.1041 mL	0.5204 mL	1.0409 mL	2.6021 mL
	30 mM	0.0867 mL	0.4337 mL	0.8674 mL	2.1684 mL
	40 mM	0.0651 mL	0.3253 mL	0.6505 mL	1.6263 mL
	50 mM	0.0520 mL	0.2602 mL	0.5204 mL	1.3011 mL
	60 mM	0.0434 mL	0.2168 mL	0.4337 mL	1.0842 mL
	80 mM	0.0325 mL	0.1626 mL	0.3253 mL	0.8132 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JS-K205432-12-8NO SynthaseApoptosisNitric oxide synthasesNOSInhibitorinhibitorinhibit

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JS-K

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稀释计算器

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