2. Cell Cycle/DNA Damage
  3. Checkpoint Kinase (Chk)
  4. K1586

K1586 是一种有效靶向 Chk1 的脒衍生物。K1586 增强 Chk1 的降解，使结直肠癌细胞对电离辐射敏感。K1586 显示出抗癌作用。

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K1586 Chemical Structure

K1586 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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K1586 相关抗体

Top Publications Citing Use of Products

查看 Checkpoint Kinase (Chk) 亚型特异性产品:

查看所有亚型
Chk1 Chk2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

K1586 is an amidine derivative that efficiently targets Chk1. K1586 enhances the degradation of Chk1 that sensitizes colorectal cancer cells to ionizing radiation. K1586 shows anticancer effects[1].

体外研究
(In Vitro)

K1586 (0.001-100 μM; 72 小时) 以剂量依赖性方式降低细胞增殖[1]。
K1586 (10-20 μM; 24 小时) 增加 S 期的相对长度，并显著增加 G2/M 期的长度[1]。
K1586 (10 μM; 12 小时) 以时间依赖性方式降低 Chk1 蛋白水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

K1586 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HT29 human colorectal cancer cells
Concentration: 0.001 μM, 0.01 μM, 0.1 μM, 1 μM, 5 μM, 10 μM, 50 μM, and 100 μM
Incubation Time: 72 h
Result: Proliferation decreased in a dose-dependent manner.

Cell Cycle Analysis[1]

Cell Line: HT29 cells
Concentration: 10 or 20 μM
Incubation Time: 24 h
Result: Increased the length of the G2/M phase in cells.

Western Blot Analysis[1]

Cell Line: HT29 cells
Concentration: 10 μM
Incubation Time: 12 h
Result: Induced Chk1 destabilization and degradation.
分子量

359.87

Formula

C18H18ClN3OS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

K1586 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

K1586K 1586K-1586Checkpoint Kinase (Chk)anticancer agentChk1 inhibitorionizing radiationamidine derivativeInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-161622
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