2. Anti-infection
  3. Antibiotic Bacterial
  4. Kanamycin

Kanamycin  (Synonyms: 卡那霉素 A; Kanamycin A)

目录号: HY-16566 纯度: 99.97%
COA 产品使用指南

摩尔计算器

Kanamycin (Kanamycin A) 是一种口服有效的抗菌剂 (革兰氏阴性/阳性细菌)，可通过与 70 S 核糖体亚单位结合，抑制转位并导致编码错误。Kanamycin 对 M. tuberculosis (敏感或耐药) 以及 K. pneumonia 均具有较好的抑制活性，可用于肺结核和肺炎的研究。

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Kanamycin Chemical Structure

Kanamycin Chemical Structure

CAS No. : 59-01-8

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规格 价格 是否有货 数量
100 mg ￥210
In-stock
200 mg ￥350
In-stock
500 mg   询价  
1 g   询价  

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Customer Review

Other Forms of Kanamycin:

Kanamycin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Kanamycin (Kanamycin A) is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia[1][2][3][4].

IC50 & Target

Aminoglycoside

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Vero IC50
> 100 μg/mL
Compound: KAN
Cytotoxicity against african green monkey Vero cells after 72 hrs by MTS-PMS assay
Cytotoxicity against african green monkey Vero cells after 72 hrs by MTS-PMS assay
[PMID: 24087924]
体外研究
(In Vitro)

Kanamycin (0.1-100 μg/mL; 2 weeks) exhibits good antibacterial activity (MIC=1-5 μg/mL) to various strains of mycobacteria in vitro[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Kanamycin 相关抗体:

Cell Viability Assay[1]

Cell Line: mycobacteria H37Rv, H2, H37RvR-PAS, Ravenel, Kirchbergand and BCG.
Concentration: 0.1-100 μg/mL
Incubation Time: 2 weeks
Result: Showed good antibacterial activity to various strains of mycobacteria (H37Rv, H2, H37RvR-PAS, Ravenel, and BCG) with MICs were 1 μg/mL and 5 μg/mL for strain of Kirchbergand.
体内研究
(In Vivo)

Kanamycin (2, 4 mg/kg; s.c.; once daily, 6 times a week for 3 weeks) inhibits growth of bovine tubercle bacilli in lung and spleen of mice[1].
Kanamycin (1.25, 5 mg/kg; s.c.; single (at 3 h after infection)) inhibits the multiplication of K. pneumonia DT-S in lung, trachea, and blood of mice and in proportion to the dose administration, and also increases the survival rate of mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Inbred strain normal mice (14-16 g; bovine tubercle bacilli (Ravenel strain) infected model)[1].
Dosage: 2, 4 mg/kg
Administration: Subcutaneous injection; once daily, 6 times a week for 3 weeks.
Result: Exerted a marked effect to inhibit the multiplication of the tuberculosis in vivo, especially in the lung of mice.
Animal Model: Slc:ICR male mice (4-week-old; 18-24 g; K. pneumonia DT-S infection model (by the aerosol method))[2].
Dosage: 1.25, 5 mg/kg
Administration: Subcutaneous administration; single (at 3 h after infection).
Result: Suppressed the growth of K. pneumonia DT-S in lung, trachea, and blood in proportion to the dose administration.
Resulted in 90% survival at 6 days after infection (negative control group: all died within 4 days), and cleared the K. pneumonia DT-S from lung, trachea, and blood of mice within 48 h (when dosage at 5 mg/kg).
Clinical Trial
分子量

484.50

Formula

C18H36N4O11
CAS 号
性状

固体

颜色

White to off-white

中文名称

卡那霉素 A
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

H2O 中的溶解度 : 70 mg/mL (144.48 mM; 超声助溶 (<60°C))

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0640 mL 10.3199 mL 20.6398 mL
5 mM 0.4128 mL 2.0640 mL 4.1280 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.97%

COA (290 KB) HNMR (269 KB) RP-HPLC (215 KB)

产品使用指南 (1538 KB)
参考文献

Kanamycin 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.0640 mL 10.3199 mL 20.6398 mL 51.5996 mL
5 mM 0.4128 mL 2.0640 mL 4.1280 mL 10.3199 mL
10 mM 0.2064 mL 1.0320 mL 2.0640 mL 5.1600 mL
15 mM 0.1376 mL 0.6880 mL 1.3760 mL 3.4400 mL
20 mM 0.1032 mL 0.5160 mL 1.0320 mL 2.5800 mL
25 mM 0.0826 mL 0.4128 mL 0.8256 mL 2.0640 mL
30 mM 0.0688 mL 0.3440 mL 0.6880 mL 1.7200 mL
40 mM 0.0516 mL 0.2580 mL 0.5160 mL 1.2900 mL
50 mM 0.0413 mL 0.2064 mL 0.4128 mL 1.0320 mL
60 mM 0.0344 mL 0.1720 mL 0.3440 mL 0.8600 mL
80 mM 0.0258 mL 0.1290 mL 0.2580 mL 0.6450 mL
100 mM 0.0206 mL 0.1032 mL 0.2064 mL 0.5160 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kanamycin59-01-8Kanamycin A卡那霉素 AAntibioticBacterialtuberculosismycobacteriabovine tubercle bacillistreptomycinK. pneumoniapneumoniaInhibitorinhibitorinhibit

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