2. Vitamin D Related/Nuclear Receptor Cell Cycle/DNA Damage Apoptosis Epigenetics
  3. Androgen Receptor CDK MDM-2/p53 Apoptosis Caspase PARP Bcl-2 Family
  4. Lambertianic acid

Lambertianic acid 是一种具有生物活性的二萜，具备抗过敏、抗细菌和抗癌活性。Lambertianic acid 可以减少雄激素受体蛋白 (androgen receptor) 水平，前列腺特异抗原的细胞和分泌水平。Lambertianic acid 还通过诱导 G1 期停滞、下调 CDK4/6 和细胞周期蛋白 D1、激活 p53, p21 和 p27 来抑制细胞增殖。Lambertianic acid 诱导细胞凋亡 (Apoptosis)，并促进相关蛋白，包括切割的 caspase-3/9、c-PARP 以及 BAX 的表达，同时抑制 BCL-2。Lambertianic acid 有望用于前列腺癌的研究。

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Lambertianic acid Chemical Structure

Lambertianic acid Chemical Structure

CAS No. : 4966-13-6

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Lambertianic acid 相关抗体

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

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  • 生物活性

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  • 参考文献

生物活性

Lambertianic acid is a bioactive diterpene with anti-allergic, antibacterial and anticancer activities. Lambertianic acid decreases androgen receptor protein levels, cellular and secretory levels of prostate-specific antigen. Lambertianic acid also suppresses cell proliferation by inducing G1 arrest, downregulating CDK4/6 and cyclin D1, activating p53, p21 and p27. Lambertianic acid induces Apoptosis and the expression of related proteins, including cleaved caspase-3/9, c-PARP and BAX, and inhibited BCl-2. Lambertianic acid is promising for research of prostate cancer[1].

分子量

316.43

Formula

C20H28O3
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Lambertianic acid 相关分类

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Keywords:

Lambertianic acid4966-13-6Androgen ReceptorCDKMDM-2/p53ApoptosisCaspasePARPBcl-2 FamilyCyclin dependent kinasepoly ADP ribose polymerasediterpeneanti-allergicantibacterialanticancerandrogen receptorprostate-specific antigencell proliferationprostate cancerInhibitorinhibitorinhibit

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