2. Others Metabolic Enzyme/Protease
  3. Others Ser/Thr Protease
  4. LM2I

LM2I 是多杀菌素(SPA)的衍生物。LM2I是精氨酸琥珀酸合成酶(ASS1)激活剂，并且是与ASS1直接相互作用的肿瘤抑制剂。LM2I 对 7 种结直肠癌细胞系和结直肠癌异种移植肿瘤中具有显著的抗增殖活性。LM2I通过EGFR途径抑制结直肠癌细胞的生长。

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LM2I Chemical Structure

LM2I Chemical Structure

CAS No. : 2055494-50-1

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1 mg ￥2448
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Customer Review

LM2I 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LM2I is a derivative of Spinosyn A (SPA). LM2I is argininosuccinate synthase (ASS1) enzyme activator, and tumor inhibitor that directly interact with ASS1. LM2I has significant antiproliferative activity in seven colorectal cancer cell-lines and xenograft tumors of colorectal cancer. LM2I inhibits colorectal cancer cell growth via the EGFR pathway[1].

IC50 & Target

Argininosuccinate synthetase (ASS1)[1]
体外研究
(In Vitro)

LM2I (0µM~10µM, 48h)结直肠癌细胞系有较强的抑制作用[1]。
LM2I(2µM, 15d)在结直肠癌细胞中抑制EGFR通路[1]。
LM2I通过EGFR抑制结直肠癌癌症细胞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LM2I 相关抗体:

Cell Viability Assay[1]

Cell Line: CRC cell（HT29, SW480, SW620, HCT116, LoVo, RKO, and DLD1)
Concentration: 0µM,1.25µM,2.5µM,3.75µM,5.00µM,6.25µM,7.5µM,8.75µM,10µM
Incubation Time: 48h
Result: Inhibited the viability of HT29, SW480, SW620, HCT116, LoVo, RKO, and DLD1 cells.

Cell Proliferation Assay[1]

Cell Line: HT29 and SW480 cells
Concentration: 0.75µM,1µM
Incubation Time: 14d
Result: Had almost no effect on EGFR-KO cells.

Western Blot Analysis[1]

Cell Line: HT29, SW480, SW620, HCT116, LoVo, RKO, DLD1 cell
Concentration: 2µM
Incubation Time: 0~15d
Result: EGFR protein levels were higher than control group.Time-dependently inhibited the protein levels of EGFR and significantly reduced relative to phosphorylation.
体内研究
(In Vivo)

LM2I (2.5 mg/kg， 腹腔注射, 每隔一天共28天) 抑制了裸鼠异种移植瘤模型肿瘤的生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female athymic BALB/c nude mice xenograft model(injected subcutaneously into the flank region with HT29 cell)[1].
Dosage: 2.5 mg/kg/day
Administration: Intraperitoneal injection,every other day for 28 days
Result: The tumor weight was significantly lower than that of the control group, and the tumor cell density was lower.
分子量

860.13

Formula

C47H77N3O11
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

纯度 & 产品资料
参考文献

LM2I 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LM2I2055494-50-1OthersSer/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesCRC cell linesBALB/c female miceColorectal cancer.Inhibitorinhibitorinhibit

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