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  3. Manganese(salen) chloride

Manganese(salen) chloride  (Synonyms: EUK-8)

目录号: HY-W001583 纯度: 97.38%
COA 产品使用指南

Manganese(salen) chloride (EUK-8),一种超氧化物歧化酶和过氧化氢酶模拟物,是具有氧自由基清除性能的抗氧化剂。Manganese(salen) chloride 可减轻内毒素血症猪的急性肺损伤。

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Manganese(salen) chloride Chemical Structure

Manganese(salen) chloride Chemical Structure

CAS No. : 53177-12-1

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥275
In-stock
5 mg ¥250
In-stock
10 mg ¥400
In-stock
50 mg   询价  
100 mg   询价  

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Manganese(salen) chloride (EUK-8), a superoxide dismutase and catalase mimetic, is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates acute lung injury in endotoxemic swine[1][2].

体外研究
(In Vitro)

Manganese(salen) chloride (25 μM; 24-72 h) protects organotypic hippocampal slices from β-AP-induced neurotoxicity, and completely blocks β-AP-induced free radical accumulation and lipid peroxidation[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Manganese(salen) chloride (25 mg/kg; i.p. 3 times a week for 4 weeks) reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild-type (WT) and harlequin (Hq) B6CBA male and female mice[3]
Dosage: 25 mg/kg/day
Administration: I.p. 3 times a week for 4 weeks
Result: Prevented myocardial oxidant damage provoked by biomechanical stress.
Improved survival following biomechanical stress.
Prevented functional and geometrical deterioration in response to pressure overload.
Attenuated necrotic and apoptotic cell death, and attenuated cardiac hypertrophy and fibrosis.
分子量

356.69

Formula

C16H14ClMnN2O2

CAS 号
性状

固体

颜色

Brown to dark brown

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验: 

DMSO 中的溶解度 : 8.33 mg/mL (23.35 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8036 mL 14.0178 mL 28.0355 mL
5 mM 0.5607 mL 2.8036 mL 5.6071 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 97.38%

参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8036 mL 14.0178 mL 28.0355 mL 70.0889 mL
5 mM 0.5607 mL 2.8036 mL 5.6071 mL 14.0178 mL
10 mM 0.2804 mL 1.4018 mL 2.8036 mL 7.0089 mL
15 mM 0.1869 mL 0.9345 mL 1.8690 mL 4.6726 mL
20 mM 0.1402 mL 0.7009 mL 1.4018 mL 3.5044 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Manganese(salen) chloride
目录号:
HY-W001583
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