1. Apoptosis Cell Cycle/DNA Damage Immunology/Inflammation NF-κB Metabolic Enzyme/Protease MAPK/ERK Pathway Stem Cell/Wnt
  2. MDM-2/p53 CDK Caspase Bcl-2 Family Reactive Oxygen Species p38 MAPK ERK JNK
  3. MAPK-IN-3

MAPK-IN-3 (Compound 4a) 是一种抗增殖剂,对 KYSE 30,HCT 116,HGC 27 表现出特别强的抑制作用,IC50 值分别为 0.57 μM,3.27 μM 和 2.28 μM。MAPK-IN-3 通过 p53 依赖机制阻滞细胞周期,并通过 p53 非依赖机制诱导细胞凋亡,下调了细胞周期相关蛋白 (如 Cyclin D1 和 cyclin B1) 的表达,上调了促凋亡蛋白 (如裂解 PARP、裂解 caspase-7 和裂解 caspase-9),并减少了抗凋亡蛋白 (如 Bcl-2) 的表达,增加了 KYSE 30 细胞内的 ROS 水平,并上调了与 ROS 相关的 MAPK 信号通路成员 (如 p-ERKp-p38p-JNK) 的表达。

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MAPK-IN-3 Chemical Structure

MAPK-IN-3 Chemical Structure

CAS No. : 2848599-79-9

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  • 生物活性

  • 纯度 & 产品资料

生物活性

MAPK-IN-3 (Compound 4a) is an anti-proliferative agent that shows particularly strong inhibitory effects on KYSE 30, HCT 116, and HGC 27, with IC50 values of 0.57 μM, 3.27 μM, and 2.28 μM, respectively. MAPK-IN-3 blocks the cell cycle via a p53-dependent mechanism and induces cell apoptosis through a p53-independent mechanism. MAPK-IN-3 downregulates the expression of cell cycle-related proteins like Cyclin D1 and cyclin B1, upregulates pro-apoptotic proteins such as cleaved PARP, cleaved caspase-7, and cleaved caspase-9, and reduces the expression of anti-apoptotic proteins like Bcl-2. Additionally, MAPK-IN-3 increases the intracellular level of ROS in KYSE 30 cells and upregulates the expression of members of the MAPK signaling pathway associated with ROS, such as p-ERK, p-p38 and p-JNK[1].

IC50 & Target

Cyclin D1

 

Cyclin B1

 

Caspase 9

 

Caspase-7

 

分子量

556.56

Formula

C28H32N2O10

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
MAPK-IN-3
目录号:
HY-169412
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