2. Academic Validation
  3. The Role of Dopamine and Its Dysfunction as a Consequence of Oxidative Stress

The Role of Dopamine and Its Dysfunction as a Consequence of Oxidative Stress

  • Oxid Med Cell Longev. 2016;2016:9730467. doi: 10.1155/2016/9730467.
Hugo Juárez Olguín 1,  David Calderón Guzmán 2,  Ernestina Hernández García 3,  Gerardo Barragán Mejía 2
Affiliations

Affiliations

  • 1 Laboratorio de Farmacología, Instituto Nacional de Pediatría (INP), 04530 Ciudad de México, DF, Mexico; Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de Mexico, 04130 Ciudad de México, DF, Mexico.
  • 2 Laboratorio de Neuroquimica, INP, 04530 Ciudad de México, DF, Mexico.
  • 3 Laboratorio de Farmacología, Instituto Nacional de Pediatría (INP), 04530 Ciudad de México, DF, Mexico.
PMID: 26770661 DOI: 10.1155/2016/9730467
Abstract

Dopamine is a neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dysfunction of the dopamine system has been implicated in different nervous system diseases. The level of dopamine transmission increases in response to any type of reward and by a large number of strongly additive drugs. The role of dopamine dysfunction as a consequence of oxidative stress is involved in health and disease. Introduce new potential targets for the development of therapeutic interventions based on antioxidant compounds. The present review focuses on the therapeutic potential of antioxidant compounds as a coadjuvant treatment to conventional neurological disorders is discussed.

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