2. Academic Validation
  3. Total synthesis of verucopeptin, an inhibitor of hypoxia-inducible factor 1 (HIF-1)

Total synthesis of verucopeptin, an inhibitor of hypoxia-inducible factor 1 (HIF-1)

  • Chem Commun (Camb). 2019 Oct 1;55(79):11956-11959. doi: 10.1039/c9cc06169j.
Nobuaki Takahashi 1,  Hideaki Hayashi 1,  Viktors Poznaks 1,  Hideaki Kakeya 1
Affiliations

Affiliation

  • 1 Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan. scseigyo-hisyo@pharm.kyoto-u.ac.jp.
PMID: 31531455 DOI: 10.1039/c9cc06169j
Abstract

Verucopeptin is an inhibitor of hypoxia-inducible factor 1 (HIF-1), which is a promising target for Cancer chemotherapy. Here, we report the first total synthesis of verucopeptin via condensation of the depsipeptide core and the polyketide side chain unit including three branched methyl groups after the synthesis of each segment.

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