2. Immunology/Inflammation
  3. COX
  4. Methylhydroquinone

Methylhydroquinone 是一种口服有效的 COX 抑制剂，靶向绵羊 COX-1 和人重组 COX-2 的 IC50s 分别为 480.7 μM 和 52.2 μM。Methylhydroquinone 具有潜在的 DNA 损伤作用：1) 通过抑制 COX-1 减少前列腺素合成，发挥抗炎活性；2) 诱导 DNA 单链断裂。Methylhydroquinone 通过竞争性结合 COX-1 的活性位点 (如 Tyr385、Met522) 及非共价相互作用发挥作用。

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Methylhydroquinone Chemical Structure

Methylhydroquinone Chemical Structure

CAS No. : 95-71-6

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10 mM * 1 mL in DMSO ￥110
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10 g ￥160
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Other Forms of Methylhydroquinone:

Methylhydroquinone 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Methylhydroquinone is an orally active COX inhibitor with IC50s of 480.7 μM and 52.2 μM for ovine COX-1 and human recombinant COX-2, respectively. Methylhydroquinone has potential DNA damaging effects: 1) inhibiting COX-1 to reduce prostaglandin synthesis and exert anti-inflammatory activity; 2) inducing DNA single-strand breaks. Methylhydroquinone exerts its effects by competitively binding to the active sites of COX-1 (such as Tyr385, Met522) and non-covalent interactions[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A2780 IC50
5.7 μM
Compound: 22
Growth inhibition of human A2780 cells after 72 hrs by SRB assay
Growth inhibition of human A2780 cells after 72 hrs by SRB assay
[PMID: 29519737]
A2780cis IC50
4.7 μM
Compound: 22
Growth inhibition of human A2780cis cells after 72 hrs by SRB assay
Growth inhibition of human A2780cis cells after 72 hrs by SRB assay
[PMID: 29519737]
OVCAR-8 IC50
6.2 μM
Compound: 22
Growth inhibition of human OVCAR8 cells after 72 hrs by SRB assay
Growth inhibition of human OVCAR8 cells after 72 hrs by SRB assay
[PMID: 29519737]
体内研究
(In Vivo)

Methylhydroquinone (200 mg/kg；胃插管，单剂量) 在大鼠胃幽门黏膜中诱导 DNA 单链断裂，增加鸟氨酸拖酸梅 (ODC) 的活性和重复 DNA 的合成 (RDS) [2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Gastric Pyloric Mucosa Injury Model in Male F344 rats (7 weeks old, 25-30 g)
Dosage: 200 mg/kg (aqueous solution)
Administration: Single gastric intubation (2 h prior to sacrifice)
Result: Significantly increased DNA single-strand breaks) in the pyloric mucosa 2 h post-administration, but did not induce detectable unscheduled DNA synthesis (UDS).
Weakly promoted tumorigenesis by increasing ornithine decarboxylase (ODC) activity (6-fold) and replicative DNA synthesis (RDS) at 24 h and 16 h, respectively.
分子量

124.14

Formula

C7H8O2
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源

Burkholderia sp. NF100.
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 100 mg/mL (805.55 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 8.0555 mL 40.2774 mL 80.5549 mL
5 mM 1.6111 mL 8.0555 mL 16.1110 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.88%

COA (284 KB) HNMR (128 KB) RP-HPLC (216 KB)

产品使用指南 (1538 KB)
参考文献

Methylhydroquinone 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 8.0555 mL 40.2774 mL 80.5549 mL 201.3872 mL
5 mM 1.6111 mL 8.0555 mL 16.1110 mL 40.2774 mL
10 mM 0.8055 mL 4.0277 mL 8.0555 mL 20.1387 mL
15 mM 0.5370 mL 2.6852 mL 5.3703 mL 13.4258 mL
20 mM 0.4028 mL 2.0139 mL 4.0277 mL 10.0694 mL
25 mM 0.3222 mL 1.6111 mL 3.2222 mL 8.0555 mL
30 mM 0.2685 mL 1.3426 mL 2.6852 mL 6.7129 mL
40 mM 0.2014 mL 1.0069 mL 2.0139 mL 5.0347 mL
50 mM 0.1611 mL 0.8055 mL 1.6111 mL 4.0277 mL
60 mM 0.1343 mL 0.6713 mL 1.3426 mL 3.3565 mL
80 mM 0.1007 mL 0.5035 mL 1.0069 mL 2.5173 mL
100 mM 0.0806 mL 0.4028 mL 0.8055 mL 2.0139 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methylhydroquinone95-71-6COXCyclooxygenaseactive compoundbiochemical studiesInhibitorinhibitorinhibit

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