2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. MEY-003

MEY-003是一种靶向 Autotaxin (ATX) 的抑制剂,其对 hATX-β 和 hATX-ɣ 的 EC50 的值分别为为 460 nM 和 1.09 μM (使用LPC18:1分析)。MEY-003 为非竞争性抑制剂，K i 指数为 432 nM。MEY-003 可用于靶向 ATX 相关疾病的研究。

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MEY-003 Chemical Structure

MEY-003 Chemical Structure

CAS No. : 3047891-88-0

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MEY-003 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MEY-003 is an Autotaxin(ATX) inhibitor with EC50s of 460 nM and 1.09 μM for hATX-β and hATX-ɣ (analysis with LPC18:1). MEY-003 behaves as a non-competitive inhibitor with K iof 432 nM. MEY-003 can be used for targeted ATX-related disease research [1].

IC50 & Target

Autotaxin

 

体外研究
(In Vitro)

MEY-003 (10 μM, 30 min) 阻断 HeLa 细胞的 LPA 信号传导，并减少 LPA1 受体内吞[1]。
MEY-003 (100 μM, 0-24 h) 对 HeLa 和 HEK293 细胞无细胞毒性作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MEY-003 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: HeLa and HEK293 cells
Concentration: 100 μM
Incubation Time: 0-24 h
Result: Showed non-cytotoxic after prolonged treatment (up to 24 h) at 100 μM with HeLa cells or HEK293 cells.
分子量

363.41

Formula

C22H21NO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MEY-003 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MEY-0033047891-88-0MEY003MEY 003Phosphodiesterase (PDE)HeLaHEK293 cellsInhibitorATXinhibitorinhibit

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