2. Cell Cycle/DNA Damage Cytoskeleton Antibody-drug Conjugate/ADC Related
  3. Kinesin ADC Payload
  4. NVP-BQS481

NVP-BQS481 (Compound 1) 是一种选择性纺锤体驱动蛋白 5 (Eg5) 抑制剂，其 IC50< 0.5 nM。NVP-BQS481 具有显著的抗有丝分裂和抗肿瘤活性 (对 SK-OV-3ip 细胞的 IC50 为 0.09 nM)。NVP-BQS481 可用作合成抗体-药物偶联物 (ADCs) 的细胞毒性有效载荷。

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NVP-BQS481

NVP-BQS481 Chemical Structure

CAS No. : 1161925-41-2

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NVP-BQS481 相关抗体

Top Publications Citing Use of Products

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NVP-BQS481 (Compound 1) is a selective Kinesin spindle protein-5 (Eg5) inhibitor with an IC50< 0.5 nM. NVP-BQS481 has significant antimitotic and antitumor activity (IC50: 0.0.9 nM for SK-OV-3ip cells). NVP-BQS481 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

Eg5

<0.5 nM ()

分子量

502.57

Formula

C27H33F3N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NVP-BQS481 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NVP-BQS4811161925-41-2KinesinADC PayloadADC CytotoxinInhibitorKinesin spindle protein-5KSP-5Eg5AntimitoticAntitumorSK-OV-3ip cellsPayloadADCsinhibitorinhibit

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目录号：
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