2. GPCR/G Protein
  3. Protease Activated Receptor (PAR)
  4. P4pal10

P4pal10 是蛋白酶激活受体 4 (PAR4) 的拮抗剂。P4pal10 可抑制血小板聚集，抑制组织因子 (TF) 诱导的凝血酶生成，并表现出抗凝和抗血栓活性。P4pal10 可减轻 Carrageenan (HY-125474) 引起的水肿和粒细胞浸润。P4pal10 可改善大鼠心肌缺血/再灌注 (I/R) 模型中的损伤。

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Custom Peptide Synthesis

P4pal10 Chemical Structure

P4pal10 Chemical Structure

CAS No. : 1021346-05-3

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规格 是否有货
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P4pal10 的其他形式现货产品:

Customer Review

Other Forms of P4pal10:

P4pal10 相关抗体

Top Publications Citing Use of Products

查看 Protease Activated Receptor (PAR) 亚型特异性产品:

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PAR1 PAR2 PAR4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

P4pal10 is an antagonist for protease-activated receptor 4 (PAR4). P4pal10 inhibits the platelet aggregation, inhibits tissue factor (TF)-induced thrombin generation, and exhibits anticoagulant and antithrombotic activities. P4pal10 reduces the oedema and the granulocyte infiltration induced by Carrageenan (HY-125474). P4pal10 ameliorates the injury in mice myocardial ischemia/reperfusion (I/R) models[1][2][3].

IC50 & Target

PAR4

 

分子量

1409.72

Formula

C65H112N22O13
CAS 号
Sequence

{Pal}-Ser-Gly-Arg-Arg-Tyr-Gly-His-Ala-Leu-Arg-NH2
Sequence Shortening

{Pal}-SGRRYGHALR-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

P4pal10 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

P4pal101021346-05-3Protease Activated Receptor (PAR)Thrombin receptorspaw inflammationoedemagranulocyte infiltrationcarrageenanInhibitorinhibitorinhibit

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目录号：
HY-P5875
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