2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. PD 174265

PD 174265 是一种有效的、细胞通透性强的、可逆的、选择性的 EGFR 抑制剂，其IC50 为 450 pM。

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PD 174265 Chemical Structure

PD 174265 Chemical Structure

CAS No. : 216163-53-0

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
5 mg ￥253
In-stock
10 mg ￥336
In-stock
25 mg ￥498
In-stock
50 mg ￥704
In-stock
100 mg ￥1106
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

PD 174265 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PD 174265 is a potent, cell-permeable, reversible, and selective inhibitor of EGFR with an IC50 of 450 pM[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A-431 GI50
0.021 μM
Compound: PD-168393
Growth inhibition of human A431 cells after 72 hrs by MTT assay
Growth inhibition of human A431 cells after 72 hrs by MTT assay
[PMID: 19969465]
BaF3 GI50
< 0.5 μM
Compound: 3d
Growth inhibition of mouse BA/F3 cells expressing EGFR Del1 mutant after 96 hrs by cell titer-glo assay
Growth inhibition of mouse BA/F3 cells expressing EGFR Del1 mutant after 96 hrs by cell titer-glo assay
[PMID: 20222733]
BaF3 GI50
< 0.5 μM
Compound: 3d
Growth inhibition of mouse BA/F3 cells expressing EGFR Del3 mutant after 96 hrs by cell titer-glo assay
Growth inhibition of mouse BA/F3 cells expressing EGFR Del3 mutant after 96 hrs by cell titer-glo assay
[PMID: 20222733]
BaF3 GI50
< 0.5 μM
Compound: 3d
Growth inhibition of mouse BA/F3 cells expressing EGFR Del5 mutant after 96 hrs by cell titer-glo assay
Growth inhibition of mouse BA/F3 cells expressing EGFR Del5 mutant after 96 hrs by cell titer-glo assay
[PMID: 20222733]
BaF3 GI50
< 0.5 μM
Compound: 3d
Growth inhibition of mouse BA/F3 cells expressing EGFR L858R mutant after 96 hrs by cell titer-glo assay
Growth inhibition of mouse BA/F3 cells expressing EGFR L858R mutant after 96 hrs by cell titer-glo assay
[PMID: 20222733]
BaF3 GI50
> 0.5 μM
Compound: 3d
Growth inhibition of mouse BA/F3 cells expressing EGFR Del3 and Thr790Met mutant after 96 hrs by cell titer-glo assay
Growth inhibition of mouse BA/F3 cells expressing EGFR Del3 and Thr790Met mutant after 96 hrs by cell titer-glo assay
[PMID: 20222733]
BaF3 GI50
> 5 μM
Compound: 3d
Growth inhibition of mouse BA/F3 cells expressing EGFR Del1 and Thr790Met mutant after 96 hrs by cell titer-glo assay
Growth inhibition of mouse BA/F3 cells expressing EGFR Del1 and Thr790Met mutant after 96 hrs by cell titer-glo assay
[PMID: 20222733]
BaF3 GI50
> 5 μM
Compound: 3d
Growth inhibition of mouse BA/F3 cells expressing EGFR Del5 and Thr790Met mutant after 96 hrs by cell titer-glo assay
Growth inhibition of mouse BA/F3 cells expressing EGFR Del5 and Thr790Met mutant after 96 hrs by cell titer-glo assay
[PMID: 20222733]
BaF3 GI50
> 5 μM
Compound: 3d
Growth inhibition of mouse BA/F3 cells expressing EGFR L858R and Thr790Met mutant after 96 hrs by cell titer-glo assay
Growth inhibition of mouse BA/F3 cells expressing EGFR L858R and Thr790Met mutant after 96 hrs by cell titer-glo assay
[PMID: 20222733]
分子量

371.23

Formula

C17H15BrN4O
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (336.72 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.6937 mL 13.4687 mL 26.9375 mL
5 mM 0.5387 mL 2.6937 mL 5.3875 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

PD 174265 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6937 mL 13.4687 mL 26.9375 mL 67.3437 mL
5 mM 0.5387 mL 2.6937 mL 5.3875 mL 13.4687 mL
10 mM 0.2694 mL 1.3469 mL 2.6937 mL 6.7344 mL
15 mM 0.1796 mL 0.8979 mL 1.7958 mL 4.4896 mL
20 mM 0.1347 mL 0.6734 mL 1.3469 mL 3.3672 mL
25 mM 0.1077 mL 0.5387 mL 1.0775 mL 2.6937 mL
30 mM 0.0898 mL 0.4490 mL 0.8979 mL 2.2448 mL
40 mM 0.0673 mL 0.3367 mL 0.6734 mL 1.6836 mL
50 mM 0.0539 mL 0.2694 mL 0.5387 mL 1.3469 mL
60 mM 0.0449 mL 0.2245 mL 0.4490 mL 1.1224 mL
80 mM 0.0337 mL 0.1684 mL 0.3367 mL 0.8418 mL
100 mM 0.0269 mL 0.1347 mL 0.2694 mL 0.6734 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD 174265216163-53-0PD174265PD-174265EGFREpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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PD 174265
目录号：
HY-112411
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