2. Metabolic Enzyme/Protease
  3. Angiotensin-converting Enzyme (ACE)
  4. Quinaprilat hydrochloride

Quinaprilat hydrochloride 是一种具有口服活性的非巯基血管紧张素转换酶 (ACE) 抑制剂，是 Quinapril 活性代谢物。Quinaprilat hydrochloride 特异性阻断血管紧张素 I 向血管收缩剂血管紧张素 II 的转化，并抑制缓激肽的降解。Quinaprilat hydrochloride 具有抗高血压剂和血管扩张剂的作用。

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Quinaprilat hydrochloride

Quinaprilat hydrochloride Chemical Structure

CAS No. : 82586-58-1

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Quinaprilat hydrochloride 的其他形式现货产品:

Other Forms of Quinaprilat hydrochloride:

Quinaprilat hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Quinaprilat hydrochloride is an orally active non-mercapto Angiotensin Converting Enzyme (ACE) inhibitor, the active metabolite of Quinapril. Quinaprilat hydrochloride specifically blocks the conversion of angiotensin I to the vasoconstrictor angiotensin II and inhibits the degradation of bradykinin. Quinaprilat hydrochloride acts as anti-hypertensive agent and vasodilator[1][2].

体外研究
(In Vitro)

Quinaprilat (5 μM) hydrochloride 介导与有机阴离子转运体 3 (hOAT3) 的相互作用，从而促进肾脏对 Quinaprilat hydrochloride 的主动分泌，使 HEK293 细胞对 Quinaprilat hydrochloride 的吸收增加 25 倍，hOAT3 对 Quinaprilat hydrochloride 的亲和力 Km 为 13.4 μM[1]。
Quinaprilat (100 nM，20 分钟) hydrochloride 可通过激活 B1 受体抑制蛋白激酶 C (PKC) 的活性，从而导致人肺微血管内皮细胞 (HLMVE) 释放 NO[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Quinaprilat hydrochloride 相关抗体:
体内研究
(In Vivo)

Quinaprilat hydrate (每日灌胃 3 mg/kg，连用 6 天) hydrochloride 与其他药物联合使用，在雄性自发性高血压大鼠 (SHR) 中表现出一定的抗高血压作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male spontaneous hypertensive rats (SHRs) (230-250 g)[1]
Dosage: 3 mg/kg
Administration: Oral gavage; every day; 6 days
Result: Caused a significant drop in blood pressure from day 1 to day 5 by combining quinapril and gemcabene while each alone had no effect. Decreased plasma concentration of quinaprilat on the fifth day.
分子量

446.92

Formula

C23H27ClN2O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Quinaprilat hydrochloride 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quinaprilat82586-58-1Angiotensin-converting Enzyme (ACE)ACE inhibitoranti-hypertensivevasodilatorangiotensinInhibitorinhibitorinhibit

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