2. Metabolic Enzyme/Protease
  3. Angiotensin-converting Enzyme (ACE)
  4. Quinaprilat

Quinaprilat  (Synonyms: 喹那普利)

目录号: HY-127026
产品使用指南

摩尔计算器

Quinaprilat 是一种具有口服活性的非巯基血管紧张素转换酶 (ACE) 抑制剂，是 Quinapril 活性代谢物。Quinaprilat 特异性阻断血管紧张素 I 向血管收缩剂血管紧张素 II 的转化，并抑制缓激肽的降解。Quinaprilat 具有抗高血压剂和血管扩张剂的作用。

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Quinaprilat Chemical Structure

Quinaprilat Chemical Structure

CAS No. : 82768-85-2

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Other Forms of Quinaprilat:

Quinaprilat 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Quinaprilat is an orally active non-mercapto Angiotensin Converting Enzyme (ACE) inhibitor, the active metabolite of Quinapril. Quinaprilat specifically blocks the conversion of angiotensin I to the vasoconstrictor angiotensin II and inhibits the degradation of bradykinin. Quinaprilat acts as anti-hypertensive agent and vasodilator[1][2].

体外研究
(In Vitro)

Quinaprilat (5 μM) mediates the interaction of organic anion transporter 3 (hOAT3) which can promote renal active secretion of quinapril that increases uptake of quinaprilat to 25-fold in HEK293 cells and hOAT3 affinity Km for quinaprilat is 13.4 μM[1].
Quinaprilat (100 nM, 20 min) can inhibit the activity of protein kinase C (PKC) by activing the B1 receptor resulting in the release of NO in human lung microvascular endothelial (HLMVE) cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Quinaprilat 相关抗体:
体内研究
(In Vivo)

Quinaprilat (oral gavage, 3 mg/kg, every day, 6 days) has some anti-hypertensive effect by combining with other drugs in male spontaneous hypertensive rats (SHRs)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male spontaneous hypertensive rats (SHRs) (230-250 g)[1]
Dosage: 3 mg/kg
Administration: Oral gavage; every day; 6 days
Result: Caused a significant drop in blood pressure from day 1 to day 5 by combining quinapril and gemcabene while each alone had no effect. Decreased plasma concentration of quinaprilat on the fifth day.
Animal Model:
Dosage:
Administration:
Result: Result: The pharmacokinetic parameters of quinaprilat
Parameter
AUC(0-24 h) 4.62 μM/h
Ae(0-24 h) 23.1 μg
renal clearance 31.0 mL/h
分子量

410.46

Formula

C23H26N2O5
CAS 号
中文名称

喹那普利
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Quinaprilat 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quinaprilat82768-85-2喹那普利Angiotensin-converting Enzyme (ACE)ACE inhibitoranti-hypertensivevasodilatorangiotensinInhibitorinhibitorinhibit

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