2. Anti-infection Cell Cycle/DNA Damage
  3. Reverse Transcriptase HIV DNA/RNA Synthesis
  4. R82913

R82913 (9-Cl-TIBO) 是一种强效且高选择性的 HIV-1 逆转录酶 (HIV-1 reverse transcriptase) 抑制剂，具有对 RNA 模板 (负链合成) 和 DNA 模板 (正链合成) 的抗病毒活性。R82913 能够抑制不同株 HIV-I 在 CEM 细胞中的复制，其 IC50 值为 0.15 μM。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

R82913 Chemical Structure

R82913 Chemical Structure

CAS No. : 126347-69-1

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

R82913 相关抗体

Top Publications Citing Use of Products

查看 HIV 亚型特异性产品:

查看所有亚型
HIV HIV-1 HIV-2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

R82913 (9-Cl-TIBO) is a potent and high selective inhibitor of HIV-1 reverse transcriptase with antiviral activity on both an RNA template (negative strand synthesis) and a DNA template (positive strand synthesis). R82913 inhibits the replication of different strains of HIV-I in CEM cells with a median IC50 value of of 0.15 μM[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
C8166 IC50
0.0015 μM
Compound: TIBO R-82913
Antiviral activity was evaluated by inhibition of HIV-1 replication in CD4+ lymphoblastoid cell line infected with HIV/IIIB strain
Antiviral activity was evaluated by inhibition of HIV-1 replication in CD4+ lymphoblastoid cell line infected with HIV/IIIB strain
10.1016/0960-894X(95)00257-T
C8166 EC50
0.002 μM
Compound: R-82913
Tested against HIV-1 111B for Inhibition of viral replication by determining reduction of syncytia formation and antigen gp120 in C8166 cells, estimated by ELISA
Tested against HIV-1 111B for Inhibition of viral replication by determining reduction of syncytia formation and antigen gp120 in C8166 cells, estimated by ELISA
10.1016/S0960-894X(97)00022-X
CEM-SS IC50
0.055 μM
Compound: R-82913
Tested for the inhibition of HIV-1 in CEM-SS cells measured using Syncytial assay
Tested for the inhibition of HIV-1 in CEM-SS cells measured using Syncytial assay
10.1016/S0960-894X(01)81224-5
CEM-SS CC50
35 μM
Compound: R-82913
Tested for the cytotoxicity against CEM-SS cells (determined by the inhibition of [3H]-thymidine uptake)
Tested for the cytotoxicity against CEM-SS cells (determined by the inhibition of [3H]-thymidine uptake)
10.1016/S0960-894X(01)81224-5
MOLT-4 IC50
0.19 μM
Compound: TIBO R-82913
Anti-HIV activity against HIV-1 in Molt-4 cells using 7-day infective assay
Anti-HIV activity against HIV-1 in Molt-4 cells using 7-day infective assay
[PMID: 7506311]
MOLT-4 IC50
19 μM
Compound: TIBO R-82913
Tested for cytotoxicity in Molt-4 cells by XTT assay
Tested for cytotoxicity in Molt-4 cells by XTT assay
[PMID: 7506311]
分子量

321.87

Formula

C16H20ClN3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

R82913 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

R82913126347-69-19-Cl-TIBOR 82913R-82913Reverse TranscriptaseHIVDNA/RNA SynthesisHuman immunodeficiency virusHIV-1 reverse transcriptaseantiviral activityRNA templateDNA templateCEM cellsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
R82913
目录号：
HY-106872
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z