Apolipoprotein A-I/APOA1 蛋白, Mouse (240a.a, HEK293, Fc)

Apolipoprotein A-I (APOA1) Protein, pivotal in cholesterol reverse transport, facilitates efflux from tissues and acts as a crucial cofactor for lecithin cholesterol acyltransferase (LCAT), promoting cholesterol excretion. As a homodimer, APOA1 is integral to the sperm activating protein complex (SPAP), interacting with APOA1BP, CLU, NDRG1, SCGB3A2, NAXE, and YJEFN3, demonstrating diverse molecular associations. Its involvement extends beyond cholesterol metabolism to influence cellular processes like spermatozoa motility and protein interactions. Apolipoprotein A-I/APOA1 Protein, Mouse (240a.a, HEK293, Fc) is the recombinant mouse-derived Apolipoprotein A-I/APOA1 protein, expressed by HEK293, with C-hFc labeled tag. The total length of Apolipoprotein A-I/APOA1 Protein, Mouse (240a.a, HEK293, Fc) is 240 a.a., with molecular weight of 55-65 kDa.

载脂蛋白 AI (APOA1) 蛋白在胆固醇逆向转运中发挥关键作用，促进其从组织流出，并作为卵磷脂胆固醇酰基转移酶 (LCAT) 的关键辅助因子，促进胆固醇从组织排泄至肝脏。该蛋白质以同二聚体形式存在，是精子激活蛋白复合物 (SPAP) 的一部分，该复合物包括 APOA1、免疫球蛋白重链、免疫球蛋白轻链和白蛋白。APOA1 还与 APOA1BP 和 CLU 相互作用，促成其多样化的分子关联。此外，它还与 NDRG1、SCGB3A2、NAXE 和 YJEFN3 结合，进一步强调了它参与胆固醇代谢以外的各种细胞过程，包括精子活力和蛋白质复合物相互作用。

Mouse

HEK293

C-hFc

Q00623 (D25-Q264)

11806  [NCBI]

55-65 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.