Cathepsin C/DPPI 蛋白, Mouse (HEK293, His)

The cathepsin C/DPPI protein is a thiol protease that acts as a dipeptidyl peptidase with multiple substrate specificities, excluding proline at the P1 position and arginine at the P2 position. It has both exopeptidase and endopeptidase functions and can activate serine proteases such as elastase, cathepsin G, and granzymes A and B. Cathepsin C/DPPI Protein, Mouse (HEK293, His) is the recombinant mouse-derived Cathepsin C/DPPI protein, expressed by HEK293, with C-10*His labeled tag.

组织蛋白酶 C/DPPI 蛋白作为硫醇蛋白酶发挥作用，表现出二肽基肽酶活性，可有效对抗多种包含极性和疏水性氨基酸的二肽底物。值得注意的是，底物中的 P1 位置不能容纳脯氨酸，P2 位置不能容纳精氨酸。这种硫醇蛋白酶显示出作为外肽酶和内肽酶的多功能性。其功能范围延伸至丝氨酸蛋白酶的激活，包括弹性蛋白酶、组织蛋白酶 G 以及颗粒酶 A 和 B。组织蛋白酶 C/DPPI 的广泛底物特异性和多功能作用突出了其在复杂的蛋白水解过程网络中的重要性，暗示其参与不同的细胞功能和调节途径。

Measured by its ability to cleave 10 μM fluorogenic peptide substrate Gly-Arg-AMC (HY-P4342) that incubate at room temperature in kinetic mode for 5 minutes. The specific activity is >8,000 pmol/min/µg.

Mouse

HEK293

C-10*His

P97821 (D25-L462)

13032

Full Length of Mature Protein

Approximately 52-56 kDa, due to the glycosylation.

• 
  Greater than 95% as determined by reducing SDS-PAGE.

溶液

Supplied as a 0.22 μm filtered solution in 20 mM MES, 150 mM NaCl, pH 5.5.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.