1. 重组蛋白
  2. CD Antigens
  3. Macrophage CD Proteins Stem Cell CD Proteins Platelet CD Proteins Erythrocyte CD Proteins Dendritic Cell CD Proteins Endothelial cell CD Proteins
  4. CD36/SR-B2 CD36/SR-B2
  5. CD36 蛋白, Mouse (HEK293, His)

CD36 蛋白, Mouse (HEK293, His)

目录号: HY-P72895
COA 产品使用指南

CD36 是一种多功能糖蛋白,作为血小板反应蛋白、纤连蛋白、胶原蛋白、β淀粉样蛋白和氧化低密度脂蛋白等的受体,也结合阴离子磷脂和长链磷脂等脂质分子。CD36 通过这些配体启动信号传导和内化,影响血管生成、炎症反应、脂肪酸代谢、味觉及膳食脂肪处理。此外,CD36 作为 TLR4:TLR6 异二聚体辅助受体,促进单核细胞/巨噬细胞的炎症反应,抑制血管生成,还是微生物二酰化脂肽的传感器,调节细胞因子产生,参与免疫反应及某些细菌的吸收。CD36 蛋白, Mouse (HEK293, His) 是重组的 CD36 蛋白,由 HEK293 表达,带有 C-His 标签。

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规格 价格 是否有货 数量
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5 μg ¥450 In-stock
10 μg ¥750 In-stock
50 μg ¥2060 In-stock
100 μg ¥3500 In-stock
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  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

CD36 is a multifunctional glycoprotein that binds to proteins such as thrombospondin, fibronectin, collagen, beta-amyloid and oxidized low-density lipoprotein, as well as lipid molecules such as anionic phospholipids and long-chain phospholipids. CD36 regulates angiogenesis, inflammatory responses, fatty acid metabolism, taste, dietary fat processing, and acts as a TLR4:TLR6 heterodimer coreceptor to mediate inflammatory responses, regulate immune responses and bacterial absorption. CD36 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD36 protein, expressed by HEK293 , with C-His labeled tag.

研究背景

CD36 是一种多功能糖蛋白,可作为多种配体的受体,包括血小板反应蛋白、纤连蛋白、胶原蛋白、β 淀粉样蛋白等蛋白质实体和氧化低密度脂蛋白 (oxLDL)、阴离子磷脂、长链磷脂等脂质分子。链脂肪酸和细菌二酰化脂肽。这些配体的结合启动信号转导和受体-配体复合物的内化,反应以配体特异性方式变化。CD36 的参与涉及肠道内的血管生成、炎症反应、脂肪酸代谢、味觉和膳食脂肪加工。糖蛋白结合长链脂肪酸,促进其细胞运输并参与肌肉脂质利用、脂肪能量储存和肠道脂肪吸收等过程。从机制上讲,脂肪酸结合激活下游激酶 LYN,导致 CD36 去棕榈酰化和小凹胞吞作用。CD36 在口腔脂肪感知中也发挥着关键作用,影响偏好,并在检测到舌头中的长链脂肪酸后导致胰胆分泌物的变化。此外,它有助于调节下丘脑腹内侧的能量和葡萄糖稳态,并作为血小板反应蛋白的受体,介导抗血管生成作用。CD36 作为 TLR4:TLR6 异二聚体的辅助受体,可促进单核细胞/巨噬细胞的炎症,对 oxLDL 或淀粉样蛋白 -β 等配体做出反应。此外,CD36 作为微生物二酰化脂肽的选择性传感器,触发 NF-κ-B 依赖性细胞因子的产生并参与对感染(包括结核分枝杆菌和恶性疟原虫)的反应。它还介导某些细菌的吸收,显示出其在各种生理过程中作为多功能且不可或缺的组成部分的作用。

生物活性

Immobilized Mouse CD36, at 1 μg/mL (100 μL/well) can bind CD36 Antibody. The ED50 for this effect is 39.38 ng/mL.

  • Immobilized Mouse CD36, at 1 μg/mL (100 μL/well) can bind CD36 Antibody. The ED50 for this effect is 39.38 ng/mL.
种属

Mouse

表达系统

HEK293

标签

C-His

蛋白编号

Q08857 (G30-K439)

基因 ID
蛋白结构
N-term
CD36 (G30-K439)
Accession # Q08857
His
C-term
中文名
重组鼠CD36蛋白
同用名
Glycoprotein IIIb; GPIIIB; PAS IV; PAS-4; Platelet glycoprotein 4; GPIV; CD36
氨基酸序列

GDMLIEKTIKREVVLEEGTTAFKNWVKTGTTVYRQFWIFDVQNPDDVAKNSSKIKVKQRGPYTYRVRYLAKENITQDPEDHTVSFVQPNGAIFEPSLSVGTEDDNFTVLNLAVAAAPHIYQNSFVQVVLNSLIKKSKSSMFQTRSLKELLWGYKDPFLSLVPYPISTTVGVFYPYNDTVDGVYKVFNGKDNISKVAIIESYKGKRNLSYWPSYCDMINGTDAASFPPFVEKSRTLRFFSSDICRSIYAVFGSEIDLKGIPVYRFVLPANAFASPLQNPDNHCFCTEKVISNNCTSYGVLDIGKCKEGKPVYISLPHFLHASPDVSEPIEGLHPNEDEHRTYLDVEPITGFTLQFAKRLQVNILVKPARKIEALKNLKRPYIVPILWLNETGTIGDEKAEMFKTQVTGKIK

分子量

75-90 kDa

纯度
  • Greater than 95% as determined by reducing SDS-PAGE.
性状

无菌粉末

组分

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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CD36 Protein, Mouse (HEK293, His)
目录号:
HY-P72895
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