NTRK1/TrkA-I 蛋白, Human (Biotinylated, sf9, Flag, Avi)

TrkA protein is an important receptor tyrosine kinase that regulates the development of the central and peripheral nervous systems and affects the proliferation, differentiation, and survival of neurons. As a high-affinity receptor for NGF, TrkA is activated upon NGF binding through homodimerization and autophosphorylation. NTRK1/TrkA-I Protein, Human (Biotinylated, sf9, Flag, Avi) is the recombinant human-derived NTRK1/TrkA-I, expressed by Sf9 insect cells , with Avi, Flag labeled tag. ,

TrkA 蛋白是一种受体酪氨酸激酶，在中枢和周围神经系统的发育和成熟中发挥着至关重要的作用，控制交感神经元和感觉神经元的增殖、分化和存活。TrkA 作为 NGF（其主要配体）的高亲和力受体发挥作用，在二聚体 NGF 配体结合后经历同二聚化、自磷酸化和激活。这种激活导致下游效应子（包括 SHC1、FRS2、SH2B1、SH2B2 和 PLCG1）的募集、磷酸化和/或激活，协调驱动细胞存活和分化的不同信号级联。TrkA 通过 GRB2-Ras-MAPK 级联、Ras-PI3 激酶-AKT1 信号传导和 NF-Kappa-B 激活等途径调节多种细胞过程。在没有配体和激活的情况下，TrkA 可能导致细胞死亡，强调神经元存活对营养因子的依赖性。有趣的是，它表现出对 NGF 的抗性，持续激活 AKT1 和 NF-kappa-B，但无法激活 Ras-MAPK 信号级联。TrkA 还拮抗抗增殖 NGF-NTRK1 信号传导，促进神经元前体分化。同种型 TrkA-III 另外在血管生成中发挥作用，并在过度表达时表现出致癌活性。

Human

Sf9 insect cells

Avi;Flag

P04629-2 (C436-G790)

4914

Greater than 80 % as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.