2. Stem Cell/Wnt Protein Tyrosine Kinase/RTK TGF-beta/Smad
  3. TGF-beta/Smad Anaplastic lymphoma kinase (ALK)
  4. RepSox hydrochloride

RepSox hydrochloride  (Synonyms: E-616452 hydrochloride; SJN 2511 hydrochloride)

目录号: HY-W707119
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RepSox hydrochloride hydrochloride 是一种有效的选择性转化生长因子-β 受体 I/激活素样激酶 5 (TGF-β-RI/ALK5) 抑制剂。RepSox hydrochloride 抑制 ALK5 自身磷酸化，IC50 值为 4 nM。RepSox hydrochloride 可用于肥胖和相关代谢疾病（如 2 型糖尿病）的研究。

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RepSox hydrochloride Chemical Structure

RepSox hydrochloride Chemical Structure

CAS No. : 2319939-07-4

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RepSox hydrochloride 的其他形式现货产品:

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RepSox hydrochloride 相关抗体

Top Publications Citing Use of Products

    RepSox hydrochloride purchased from MCE. Usage Cited in: Oncotarget. 2017 Jun 19;8(36):60159-60172.  [Abstract]

    SH-SY5Y (A) and HEK293 cells (B) are treated with 25 μM RepSox (Rep) in absence or presence of dPA or dPPA for 72 h, and the Western blotting results show that dPA or dPPA increases the expression in the presence of RepSox. RepSox does not cause significant alteration of furin protein compared to control. The expression of furin remains significantly increased after dPA or dPPA in the presence of RepSox.

    • 生物活性

    • 纯度 & 产品资料

    生物活性

    RepSox hydrochloride is a potent and selective inhibitor of transforming growth factor-β receptor I/activin-like kinase 5 (TGF-β-RI/ALK5). RepSox hydrochloride inhibits ALK5 autophosphorylation with an IC50 value of 4 nM. RepSox hydrochloride can be used in the study of obesity and related metabolic diseases such as type 2 diabetes.

    分子量

    323.78

    Formula

    C17H14ClN5
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料

    RepSox hydrochloride 相关分类

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    • 稀释计算器

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    The dilution calculator equation

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    RepSox2319939-07-4E-616452SJN 2511E616452E 616452SJN2511SJN-2511TGF-beta/SmadAnaplastic lymphoma kinase (ALK)Transforming growth factor betaAnaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246Inhibitorinhibitorinhibit

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