2. Others GPCR/G Protein Neuronal Signaling
  3. Isotope-Labeled Compounds Adrenergic Receptor
  4. Silodosin-d4

Silodosin-d4  (Synonyms: 西洛多辛 d4)

目录号: HY-10122S
产品使用指南 技术支持

Silodosin-d4 是 Silodosin 的氘代物。Silodosin (KAD 3213; KMD 3213) 是一个强效的、有选择性的、口服活性的 α1A-adrenergic receptor (α1A-AR) 阻滞剂。Silodosin 对 α1A-AR 表现出高度的亲和力 (Ki=0.036 nM)，是 α1B-AR 和 α1D-AR 亲和力的 162 和 50 倍，Ki 值分别为 21 nM 和 2.0 nM。Silodosin 是一种有效且耐受性良好的试剂，可用于 LUTS/BPH 的研究。

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Silodosin-d<sub>4</sub> Chemical Structure

Silodosin-d4 Chemical Structure

CAS No. : 1426173-86-5

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规格 价格 是否有货 数量
1 mg ￥15379
3 - 4 周
5 mg   询价  
10 mg   询价  

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Other Forms of Silodosin-d4:

Silodosin-d4 相关抗体

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α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Silodosin-d4 is the deuterium labeled Silodosin. Silodosin (KAD 3213) is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker. Silodosin exhibits high affinity for α1A-AR (Ki=0.036 nM), over 162-fold and 50-fold than for α1B-AR and α1D-AR with Ki values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH[1][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Silodosin-d4 相关抗体:
分子量

499.56

Formula

C25H28D4F3N3O4
CAS 号
非标记 CAS
中文名称

西洛多辛 d4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Silodosin-d4 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Silodosin-d41426173-86-5西洛多辛 d4Isotope-Labeled CompoundsAdrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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