2. Anti-infection
  3. Dengue virus Flavivirus
  4. Sinococuline

Sinococuline 是一种有效的抗登革热病毒 (dengue virus) 剂，对所有四种登革热病毒 (DENV) 血清型均有效。Sinococuline 也是一种有效的肿瘤细胞生长抑制剂。

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Sinococuline Chemical Structure

Sinococuline Chemical Structure

CAS No. : 109351-36-2

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Sinococuline 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sinococuline is a potent anti-dengue agent that is effective against all four serotypes of dengue virus (DENV). Sinococuline is also an effective tumor cell growth inhibitor[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Hepatocyte IC50
4.5 μM
Compound: 2
Antimalarial activity against Plasmodium yoelii 265 sporozoites in primary mice (Mus musculus) hepatocytes after 48 hrs
Antimalarial activity against Plasmodium yoelii 265 sporozoites in primary mice (Mus musculus) hepatocytes after 48 hrs
[PMID: 18456502]
体外研究
(In Vitro)

Sinococuline (0.5-5.0 μg/mL; 6 days) inhibits the non-structural protein-1 (NS1) release by DENV-2 infected Vero cells[1].
Sinococuline (0-40 μg/mL; 48 h) inhibits pan-DENV infection in Vero cells, with IC50s of 0.2, 0.08, 0.17, and 0.1 μg/mL for DENV-1, DENV-2, DENV-3, and DENV-4, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sinococuline 相关抗体:
体内研究
(In Vivo)

Sinococuline (0.5-2.0 mg/kg/day; i.p. twice a day for 5 days) decreases the morbidity and increases the survival of severely DENV-infected AG129 mice, with no body weight change[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: AG129 mouse (an interferon type I and II receptor-deficient mice) with severe DENV-infection[1]
Dosage: 0.5, 1.0, 2.0 mg/kg/day
Administration: I.p. twice a day for 5 days
Result: Showed delayed mortality and survived significantly of mice, but none of the mice could survive till the end of experiment at the dose of 0.5 mg/kg/day.
The mice completely survived through the entire course of experiment at the dose of 2.0 mg/kg/day.
分子量

333.38

Formula

C18H23NO5
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Sinococuline 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sinococuline109351-36-2Dengue virusFlavivirusDENVdenguevirustumorInhibitorinhibitorinhibit

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