2. Apoptosis
  3. Survivin
  4. Survivin-IN-2

Survivin-IN-2 是一种 survivin 抑制剂。Survivin-IN-2 对 C4-2 细胞和 PC-3 细胞具有细胞毒性作用，其 IC50 值分别为 0.53 μM 和 1.06 μM。Survivin-IN-2 能有效抑制异种移植瘤的生长且无明显毒性，并可降低肿瘤组织中的 survivin 蛋白水平。Survivin-IN-2 可用于前列腺癌的相关研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Survivin-IN-2

Survivin-IN-2 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Survivin-IN-2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Survivin-IN-2 is a survivin inhibitor. Survivin-IN-2 shows cytotoxicity in cells with IC50s of 0.53 μM (C4-2 cells) and 1.06 μM (PC-3 cells). Survivin-IN-2 effectively suppresses xenograft tumor growth without apparent toxicity and eliminates survivin in the tumors. Survivin-IN-2 can be used for the study of prostate cancer[1].

体外研究
(In Vitro)

Survivin-IN-2 (Compound 7I14) (1 μM, 48 h) 可降低 C4-2 和 PC-3 细胞中 survivin 的表达[1]。
Survivin-IN-2 (450-1000 nM) 在 survivin 过表达的 C4-2 细胞和 Docetaxel (HY-B0011) 耐受的 DU145细胞 (DU145Doc) 中的细胞毒性活性降低[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Survivin-IN-2 相关抗体:
体内研究
(In Vivo)

Survivin-IN-2 (Compound 7I14) (15 mg/kg，腹腔注射，每周两次，持续四周) 可抑制 PC-3 细胞异种移植小鼠的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NSG mice implanted with PC-3 xenograft tumors[1]
Dosage: 15 mg/kg
Administration: i.p. twice a week for four weeks
Result: Suppressed the growth of the PC-3 xenograft tumors.
Upregulated the level of cleaved caspase-3.
Reduced the survivin level.
Did not significantly affect the body weight of the treated mice compared with the control mice.
分子量

448.36

Formula

C22H14F6N4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Survivin-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Survivin-IN-2SurvivinC4-2 cellsPC-3 cellscancerInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Survivin-IN-2
目录号：
HY-175017
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z