2. Metabolic Enzyme/Protease GPCR/G Protein Cell Cycle/DNA Damage Epigenetics Apoptosis NF-κB TGF-beta/Smad Stem Cell/Wnt
  3. Endogenous Metabolite G protein-coupled Bile Acid Receptor 1 PARP Apoptosis NF-κB PKA
  4. Taurodeoxycholate-d6 sodium salt

Taurodeoxycholate-d6 sodium salt  (Synonyms: 牛磺脱氧胆酸钠-d6)

目录号: HY-128853S
产品使用指南 技术支持

Taurodeoxycholate-d6 sodium salt 是一种胆盐相关的阴离子洗涤剂。Taurodeoxycholate-d6 sodium salt 是在肝脏中将脱氧胆酸与 Taurine (HY-B0351) 偶联形成的。Taurodeoxycholate-d6 sodium salt 可用于分离膜蛋白，包括线粒体内膜蛋白。Taurodeoxycholate-d6 (TDCA) 具有抗炎和神经保护作用。。

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Taurodeoxycholate-d<sub>6</sub> sodium salt Chemical Structure

Taurodeoxycholate-d6 sodium salt Chemical Structure

CAS No. : 2687960-92-3

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规格 价格 是否有货 数量
1 mg ￥6500
3 - 4 周
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Other Forms of Taurodeoxycholate-d6 sodium salt:

Taurodeoxycholate-d6 sodium salt 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Taurodeoxycholate-d6 sodium salt is a bile salt-related anionic detergent. Taurodeoxycholate-d6 sodium salt is formed in the liver by conjugation of deoxycholate with Taurine (HY-B0351). Taurodeoxycholate-d6 sodium salt is used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholate-d6 (TDCA) exhibits anti-inflammatory and neuroprotective effects[1][2][3][9][10].

体外研究
(In Vitro)

Taurodeoxycholate-d6 sodium salt (Taurodeoxycholic acid form) 通过荧光素酶检测，对 CHO 细胞中表达的人 TGR5 具有激动活性，EC50 为 0.79 μM[4]。
Taurodeoxycholate-d6 sodium salt (Taurodeoxycholic acid form, 16 h) 对在 HEK293 细胞中表达的野生型和 Y89A 突变型人 TGR5 具有激动剂活性，其 EC50 分别为 0.68 和 8.9 μM (以细胞内 cAMP 水平的升高来评估)[5]。
Taurodeoxycholate-d6 sodium salt (Taurodeoxycholic acid form, 50-100 μM，4 h) 增加原代人肝细胞中寡核体 DNA 切割和细胞核凋亡[6]。
Taurodeoxycholate-d6 sodium salt (Taurodeoxycholic acid form, 400 μM，18-24 h) 在人肝来源的 Huh7 细胞中增加 DNA 碎片和 PARP 切割，诱导凋亡[7]。
Taurodeoxycholate-d6 (0.05-1.00 mM，1-6 天) sodium salt 刺激肠上皮细胞增殖[8]。
Taurodeoxycholate-d6 (0.05-1.00 mM，24 h) sodium salt 诱导细胞周期的S期浓度显著增加和 G1 期浓度显著降低，增加c-myc IEC-6细胞蛋白和 mRNA 的表达[8]。
Taurodeoxycholate-d6 (25-400 ng/mL，稀释四倍，3 h) sodium salt 通过激活 cAMP-PKA 轴，抑制脂多糖激活的骨髓源性巨噬细胞 (BMDMs) 中 NF-κB 的活化[9]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Taurodeoxycholate-d6 sodium salt 相关抗体:

Cell Proliferation Assay[8]

Cell Line: IEC-6 and caco-2 cells
Concentration: 0, 0.05, 0.50, and 1.00 mM
Incubation Time: 1, 2, 4 and 6 days
Result: Significantly stimulated intestinal epithelial cell proliferation in a dose-dependent manner.

Cell Cycle Analysis[8]

Cell Line: IEC-6 cells
Concentration: 0, 0.05, 0.50, and 1.00 mM
Incubation Time: 24 h
Result: Significantly increased cells in S phase and decreased cells in G1-phase.

Western Blot Analysis[8]

Cell Line: IEC-6 cells
Concentration: 0.5 mM
Incubation Time: 1 and 6 days
Result: Significantly increased c-myc protein expression.
体内研究
(In Vivo)

Taurodeoxycholate-d6 (1.25-5 mg/kg，口服，6 天) sodium salt 可改善右旋糖酐硫酸钠 (DSS) 诱导的小鼠结肠炎[9]。
Taurodeoxycholate-d6 sodium salt (Taurodeoxycholic acid form，50 mg/kg，腹腔注射，每天 1 次，共 34 天) 预防亨廷顿舞蹈病 (HD) 大鼠模型的神经病理和相关的行为缺陷[10]。
Taurodeoxycholate-d6 sodium salt (Taurodeoxycholic acid form，500 mg/kg，皮下注射，每 3 天 1 次，共 7 周) 导致 R6/2 转基因 HD 小鼠纹状体神经病理的显著降低[11]。
Taurodeoxycholate-d6 (0.5 mg/kg，静脉注射，一次) sodium salt 对患有脓毒症的 C57BL/6N 小鼠提供保护，但不能保护患有脓毒症的 TGR5 KO 小鼠[12]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A mouse colitis model (fed with 3% (w/v) DSS in drinking water for the first seven days and then switched to normal drinking water for an additional two days)[9]
Dosage: 1.25, 2.5, and 5 mg/kg
Administration: Oral gavage (p.o.), from day 3 to day 8, once a day
Result: Prevented loss of body weight, shortening of the colon, production of pro-inflammatory cytokines, infiltration of pro-inflammatory cells, and mucosal ulceration in the colon.
Animal Model: Huntington's disease model in mouse[10]
Dosage: 50 mg/kg
Administration: Intraperitoneal injection; once daliy for 34 d, injected 3-NP at 6 hr after Taurodeoxycholic acid treatment
Result: Reduced striatal atrophy, decreased striatal apoptosis, as well as fewer and smaller size ubiquitinated neuronal intranuclear huntingtin inclusions.
Significantly improved locomotor and sensorimotor deficits.
Animal Model: C57BL/6N mice, Lipopolysaccharides (HY-D1056) injection model of sepsis[12]
Dosage: 0.5 mg/kg
Administration: Intravenous injection, 30 min or 24 h after LPS injection
Result: Improved the survival rate of mice with sepsis.
Decreased liver and kidney damage in septic mice.
Ameliorated systemic inflammation and normalized blood pressure in septic mice.
分子量

528.73

Formula

C26H39D6NNaO6S
CAS 号
非标记 CAS
中文名称

牛磺脱氧胆酸钠-d6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Taurodeoxycholate-d6 sodium salt 相关分类

  • 摩尔计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Taurodeoxycholate-d62687960-92-3牛磺脱氧胆酸钠-d6Endogenous MetaboliteG protein-coupled Bile Acid Receptor 1PARPApoptosisNF-κBPKAG-protein coupled receptor 19GPCR19TGR5GPBAR1poly ADP ribose polymerase Nuclear factor-κBNuclear factor-kappaBProtein kinase ABMDMsCHOHuh7IEC-6Huntington's diseaseColitisAnti-inflammatory.Inhibitorinhibitorinhibit

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