2. GPCR/G Protein Metabolic Enzyme/Protease Cell Cycle/DNA Damage Epigenetics Apoptosis NF-κB TGF-beta/Smad Stem Cell/Wnt
  3. G protein-coupled Bile Acid Receptor 1 Endogenous Metabolite PARP Apoptosis NF-κB PKA
  4. Sodium taurodeoxycholate hydrate

Sodium taurodeoxycholate hydrate  (Synonyms: 牛磺脱氧胆酸钠水合物)

目录号: HY-W089835 纯度: ≥97.0%
COA 产品使用指南 技术支持

Sodium taurodeoxycholate hydrate 是一种胆盐相关的阴离子洗涤剂。Sodium taurodeoxycholate hydrate 是在肝脏中将脱氧胆酸与 Taurine (HY-B0351) 偶联形成的。Sodium taurodeoxycholate hydrate 可用于分离膜蛋白，包括线粒体内膜蛋白。Taurodeoxycholate-d6 (TDCA) 具有抗炎和神经保护作用。。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Sodium taurodeoxycholate hydrate Chemical Structure

Sodium taurodeoxycholate hydrate Chemical Structure

CAS No. : 207737-97-1

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥231
In-stock
100 mg ￥210
In-stock
500 mg ￥500
In-stock
1 g   询价  
5 g   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Sodium taurodeoxycholate hydrate:

Sodium taurodeoxycholate hydrate 相关抗体

Top Publications Citing Use of Products

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 PKA 亚型特异性产品:

查看所有亚型
PKA PKAR

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sodium taurodeoxycholate hydrate is a bile salt-related anionic detergent. Sodium taurodeoxycholate hydrate is formed in the liver by conjugation of deoxycholate with Taurine (HY-B0351). Sodium taurodeoxycholate hydrate is used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholate-d6 (TDCA) exhibits anti-inflammatory and neuroprotective effects[1][2][3][9][10].

IC50 & Target

Microbial Metabolite

 

体外研究
(In Vitro)

Sodium taurodeoxycholate hydrate (Taurodeoxycholic acid form) 通过荧光素酶检测，对 CHO 细胞中表达的人 TGR5 具有激动活性，EC50 为 0.79 μM[4]。
Sodium taurodeoxycholate hydrate (Taurodeoxycholic acid form, 16 h) 对在 HEK293 细胞中表达的野生型和 Y89A 突变型人 TGR5 具有激动剂活性，其 EC50 分别为 0.68 和 8.9 μM (以细胞内 cAMP 水平的升高来评估)[5]。
Sodium taurodeoxycholate hydrate (Taurodeoxycholic acid form, 50-100 μM，4 h) 增加原代人肝细胞中寡核体 DNA 切割和细胞核凋亡[6]。
Sodium taurodeoxycholate hydrate (Taurodeoxycholic acid form, 400 μM，18-24 h) 在人肝来源的 Huh7 细胞中增加 DNA 碎片和 PARP 切割，诱导凋亡[7]。
Sodium taurodeoxycholate hydrate (0.05-1.00 mM，1-6 天) 刺激肠上皮细胞增殖[8]。
Sodium taurodeoxycholate hydrate (0.05-1.00 mM，24 h) 诱导细胞周期的S期浓度显著增加和 G1 期浓度显著降低，增加c-myc IEC-6细胞蛋白和 mRNA 的表达[8]。
Sodium taurodeoxycholate hydrate (25-400 ng/mL，稀释四倍，3 h) 通过激活 cAMP-PKA 轴，抑制脂多糖激活的骨髓源性巨噬细胞 (BMDMs) 中 NF-κB 的活化[9]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sodium taurodeoxycholate hydrate 相关抗体:

Cell Proliferation Assay[8]

Cell Line: IEC-6 and caco-2 cells
Concentration: 0, 0.05, 0.50, and 1.00 mM
Incubation Time: 1, 2, 4 and 6 days
Result: Significantly stimulated intestinal epithelial cell proliferation in a dose-dependent manner.

Cell Cycle Analysis[8]

Cell Line: IEC-6 cells
Concentration: 0, 0.05, 0.50, and 1.00 mM
Incubation Time: 24 h
Result: Significantly increased cells in S phase and decreased cells in G1-phase.

Western Blot Analysis[8]

Cell Line: IEC-6 cells
Concentration: 0.5 mM
Incubation Time: 1 and 6 days
Result: Significantly increased c-myc protein expression.
体内研究
(In Vivo)

Sodium taurodeoxycholate hydrate (1.25-5 mg/kg，口服，6 天) 可改善右旋糖酐硫酸钠 (DSS) 诱导的小鼠结肠炎[9]。
Sodium taurodeoxycholate hydrate (Taurodeoxycholic acid form，50 mg/kg，腹腔注射，每天 1 次，共 34 天) 预防亨廷顿舞蹈病 (HD) 大鼠模型的神经病理和相关的行为缺陷[10]。
Sodium taurodeoxycholate hydrate (Taurodeoxycholic acid form，500 mg/kg，皮下注射，每 3 天 1 次，共 7 周) 导致 R6/2 转基因 HD 小鼠纹状体神经病理的显著降低[11]。
Sodium taurodeoxycholate hydrate (0.5 mg/kg，静脉注射，一次) 对患有脓毒症的 C57BL/6N 小鼠提供保护，但不能保护患有脓毒症的 TGR5 KO 小鼠[12]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A mouse colitis model (fed with 3% (w/v) DSS in drinking water for the first seven days and then switched to normal drinking water for an additional two days)[9]
Dosage: 1.25, 2.5, and 5 mg/kg
Administration: Oral gavage (p.o.), from day 3 to day 8, once a day
Result: Prevented loss of body weight, shortening of the colon, production of pro-inflammatory cytokines, infiltration of pro-inflammatory cells, and mucosal ulceration in the colon.
Animal Model: Huntington's disease model in mouse[10]
Dosage: 50 mg/kg
Administration: Intraperitoneal injection; once daliy for 34 d, injected 3-NP at 6 hr after Taurodeoxycholic acid treatment
Result: Reduced striatal atrophy, decreased striatal apoptosis, as well as fewer and smaller size ubiquitinated neuronal intranuclear huntingtin inclusions.
Significantly improved locomotor and sensorimotor deficits.
Animal Model: C57BL/6N mice, Lipopolysaccharides (HY-D1056) injection model of sepsis[12]
Dosage: 0.5 mg/kg
Administration: Intravenous injection, 30 min or 24 h after LPS injection
Result: Improved the survival rate of mice with sepsis.
Decreased liver and kidney damage in septic mice.
Ameliorated systemic inflammation and normalized blood pressure in septic mice.
分子量

521.69

Formula

C26H44NNaO6S
CAS 号
性状

固体

颜色

White to off-white

中文名称

牛磺脱氧胆酸钠水合物
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 100 mg/mL (191.68 mM; 超声助溶)

DMSO 中的溶解度 : 100 mg/mL (191.68 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9168 mL 9.5842 mL 19.1685 mL
5 mM 0.3834 mL 1.9168 mL 3.8337 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: ≥97.0%

COA (290 KB)

产品使用指南 (1538 KB)
参考文献

Sodium taurodeoxycholate hydrate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.9168 mL 9.5842 mL 19.1685 mL 47.9212 mL
5 mM 0.3834 mL 1.9168 mL 3.8337 mL 9.5842 mL
10 mM 0.1917 mL 0.9584 mL 1.9168 mL 4.7921 mL
15 mM 0.1278 mL 0.6389 mL 1.2779 mL 3.1947 mL
20 mM 0.0958 mL 0.4792 mL 0.9584 mL 2.3961 mL
25 mM 0.0767 mL 0.3834 mL 0.7667 mL 1.9168 mL
30 mM 0.0639 mL 0.3195 mL 0.6389 mL 1.5974 mL
40 mM 0.0479 mL 0.2396 mL 0.4792 mL 1.1980 mL
50 mM 0.0383 mL 0.1917 mL 0.3834 mL 0.9584 mL
60 mM 0.0319 mL 0.1597 mL 0.3195 mL 0.7987 mL
80 mM 0.0240 mL 0.1198 mL 0.2396 mL 0.5990 mL
100 mM 0.0192 mL 0.0958 mL 0.1917 mL 0.4792 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sodium taurodeoxycholate207737-97-1牛磺脱氧胆酸钠水合物G protein-coupled Bile Acid Receptor 1Endogenous MetabolitePARPApoptosisNF-κBPKAG-protein coupled receptor 19GPCR19TGR5GPBAR1poly ADP ribose polymerase Nuclear factor-κBNuclear factor-kappaBProtein kinase ABMDMsCHOHuh7IEC-6Huntington's diseaseColitisAnti-inflammatory.Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Sodium taurodeoxycholate hydrate
目录号：
HY-W089835
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z