2. Membrane Transporter/Ion Channel
  3. Proton Pump Na+/K+ ATPase
  4. Tegoprazan-d6

Tegoprazan-d6  (Synonyms: CJ-12420-d6; RQ-00000004-d6)

目录号: HY-17623S
产品使用指南

摩尔计算器

Tegoprazan (CJ-12420; RQ-00000004)，一种钾竞争酸阻滞剂，是一种可逆的、口服活性的、高选择性的胃 H+/K+- ATP 酶抑制剂，可以控制胃酸分泌和运动，体外猪、犬和人的 H+/K+- ATP 酶的 IC50 值在 0.29-0.52 μM 之间。Tegoprazan 可显著改善小鼠结肠炎，增强肠上皮屏障功能。Tegoprazan 有望用于肠炎、胃酸相关、运动障碍性疾病的研究 。

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Tegoprazan-d<sub>6</sub> Chemical Structure

Tegoprazan-d6 Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥8500
1 - 2 周
5 mg   询价  
10 mg   询价  

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Tegoprazan-d6 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tegoprazan (CJ-12420; RQ-00000004), a potassium-competitive acid blocker, is a reversible, oral active and highly selective inhibitor of gastric H+/K+-ATPase that could control gastric acid secretion and motility, with IC50 values ranging from 0.29-0.52 μM for porcine, canine, and human H+/K+-ATPases in vitro. Tegoprazan significantly improves colitis in mice and enhances the intestinal epithelial barrier function. Tegoprazan is promising for research of Inflammatory bowel, gastric acid-related, motilityimpaired diseases[1][2][3].
体外研究
(In Vitro)

Tegoprazan (1.0 mM and 3.0 mM, 4 h) 通过维持 Caco-2 细胞上皮粘膜的高连接完整性来减少 DSS 诱导的结肠炎[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tegoprazan-d6 相关抗体:

RT-PCR[1]

Cell Line: Caco-2 cells
Concentration: 1.0 mM and 3.0 mM
Incubation Time: 4 h
Result: Protected the intestinal epithelial tight junction barrier and inhibits the increase in intestinal permeability.
体内研究
(In Vivo)

Tegoprazan (30 mg/kg, 口服, 每天两次, 持续 5 天) 减轻了二硝基苯磺酸 (DNBS) 诱导的结肠长度和结肠损伤的严重程度，以及保护小鼠结肠免受 DNBS 诱导的结肠炎症[1]。
Tegoprazan (3 mg/kg 和 10 mg/kg, 口服, 5 h) 以剂量依赖的方式抑制基础胃酸分泌[2]。
Tegoprazan (0.1, 1 和 10 mg/kg, 口服) 具有剂量依赖性的抗溃疡作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pylorus-Ligated Rats[2]
Dosage: 3 mg/kg and 10 mg/kg
Administration: p.o., a single dose
Result: Inhibited basal gastric acid secretion in a dose-dependent manner and was effective at a single dose in Pylorus-Ligated rats.
Animal Model: Naproxen-induced acute gastric ulcer rat model[2]
Dosage: 0.1, 1 and 10 mg/kg
Administration: p.o., a single day or daily for 5 days
Result: Exerted an antiulcer effect in a dose-dependent manner and was effective at a single dose in naproxen-induced acute gastric ulcer rat model.
Animal Model: DNBS and Tegoprazan-induced rats[2]
Dosage: 30 mg/kg
Administration: p.o., twice daily for 5 days
Result: Reduced mRNA expression levels of proinflammatory cytokines, especially interleukin-17 (IL17) in DNBS and Tegoprazan-induced rats.
分子量

393.42

Formula

C20H13D6F2N3O3
非标记 CAS

942195-55-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tegoprazan-d6 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tegoprazan-d6CJ-12420-d6 RQ-00000004-d6Proton PumpNa+/K+ ATPaseSodium potassium pumpacid blockerreversibleoral activehighly selectivegastric acid secretioncolitisInflammatory bowelInhibitorinhibitorinhibit

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