2. Cell Cycle/DNA Damage Apoptosis
  3. Topoisomerase Apoptosis Caspase
  4. Topoisomerase I inhibitor 2

Topoisomerase I inhibitor 2 (ZML-8) 是一种高度选择性的 DNA topoisomerase I (Top1) 抑制剂。Topoisomerase I inhibitor 2 抑制 Top1 活性，导致 DNA 损伤。Topoisomerase I inhibitor 2 还能够阻断 G2/M 期，诱导细胞凋亡 (apoptosis)，具有抗肿瘤作用。

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Topoisomerase I inhibitor 2 Chemical Structure

Topoisomerase I inhibitor 2 Chemical Structure

CAS No. : 2588211-44-1

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Topoisomerase I inhibitor 2 相关抗体

Top Publications Citing Use of Products

查看 Topoisomerase 亚型特异性产品:

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Topoisomerase Topo I Topo II

查看 Caspase 亚型特异性产品:

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Topoisomerase I inhibitor 2 (ZML-8) is a highly selective inhibitor of DNA topoisomerase I (Top1). Topoisomerase I inhibitor 2 inhibits Top1 activity and results DNA damage. Topoisomerase I inhibitor 2 blocks G2/M phase and induces apoptosis, exhibits anti-tumor effect[1].

IC50 & Target

Topoisomerase I

0.58 μM (IC50)

体外研究
(In Vitro)

Topoisomerase I inhibitor 2 (ZML-8) (24 hours) exhibits strong inhibition with an IC50 value of 0.58 μM towards HepG2 and selective activity with SI values (selectivity index) of 55.70% between HepG2 and normal human liver cell line L-02[1].
Topoisomerase I inhibitor 2 (1.25, 2.5 μM, 48 hours) inhibits tumor cells proliferation by decreasing anti-apoptotic expression of Bcl-2 and enhancing caspase-dependent apoptosis[1].
Topoisomerase I inhibitor 2 (1.25, 2.5 μM, 48 hours) decreases Top1 specific activity and results in DNA damage by causing supercoiled DNA[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Topoisomerase I inhibitor 2 相关抗体:

Cell Cycle Analysis[1]

Cell Line: HepG2 cells
Concentration: 2.5 μM
Incubation Time: 24 hours
Result: Arrested the cell cycle in G2/M phase in a dose-dependent manner.

Cell Proliferation Assay[1]

Cell Line: HepG2 cells
Concentration: 0.625, 1.25, 2.5 μM
Incubation Time: 48 hours
Result: Inhibited tumor cells proliferation by inducing cell apoptosis in a dose-dependent manner, the apoptosis rate was 65.0% and 77.6%, respectively.

Western Blot Analysis[1]

Cell Line: HepG2 cells
Concentration: 0.625, 1.25, 2.5 μM
Incubation Time: 48 hours
Result: Decreased anti-apoptotic expression of Bcl-2 at 2.5 μM significantly and increased the expression of pro-apoptotic protein Bax, Bad, and p53. And also significantly enhanced caspase- dependent apoptosis and activated Cleaved caspase-3 in a dose-dependent manner.
分子量

293.32

Formula

C18H15NO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Topoisomerase I inhibitor 2 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topoisomerase I inhibitor 22588211-44-1Topoisomerase I inhibitor2Topoisomerase I inhibitor-2TopoisomeraseApoptosisCaspaseanti-tumorDNA topoisomerase ITop1non-camptothecinCPTDNA damageHepG2apoptosisInhibitorinhibitorinhibit

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