2. Cell Cycle/DNA Damage Apoptosis
  3. Topoisomerase Apoptosis
  4. Topoisomerase II inhibitor 20

Topoisomerase II inhibitor 20 

目录号: HY-158061
产品使用指南

摩尔计算器

Topoisomerase II inhibitor 20 (Compound 3e) 是一种有效的拓扑异构酶 II (Topoisomerase II) 抑制剂，IC50 为 0.98 µM。Topoisomerase II inhibitor 20 可诱导细胞凋亡 (apoptosis) 且具有广谱抗癌活性。

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Topoisomerase II inhibitor 20 Chemical Structure

Topoisomerase II inhibitor 20 Chemical Structure

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Topoisomerase II inhibitor 20 相关抗体

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Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Topoisomerase II inhibitor 20 (Compound 3e) is a potent topoisomerase II (Topoisomerase II) inhibitor with an IC50 of 0.98 µM. Topoisomerase II inhibitor 20 induces apoptosis and has broad-spectrum anticancer activity[1].

IC50 & Target

Topoisomerase II

0.98 μM (IC50)

体外研究
(In Vitro)

Topoisomerase II inhibitor 20 (1.90 µM; 24 h) 表现出细胞阻滞在G2-M期，从而抑制细胞增殖并诱导细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Topoisomerase II inhibitor 20 相关抗体:

Cell Cycle Analysis[1]

Cell Line: Leukemia SR cells
Concentration: 1.90 µM
Incubation Time: 24 h
Result: caused a significant increase in the G2-M phase with 49.26% in comparison to control (5.25%).
分子量

459.51

Formula

C22H23F2N5O2S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Topoisomerase II inhibitor 20 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topoisomerase II inhibitor 20Topoisomerase II inhibitor20Topoisomerase II inhibitor-20TopoisomeraseApoptosisanticancerSK-MEL-5 cellleukemiamelanomalungcolonCNSovarianrenalprostatebreast cancerInhibitorinhibitorinhibit

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