2. Cell Cycle/DNA Damage Apoptosis
  3. Topoisomerase Apoptosis
  4. Topoisomerase II inhibitor 9

Topoisomerase II inhibitor 9 (Compound 19b) 是一种 Topo II 抑制剂，IC50 为 0.97 μM。Topoisomerase II inhibitor 9 也是一种 DNA 嵌入剂，IC50 为 43.51 μM。Topoisomerase II inhibitor 9 在 G2/M 期阻滞 Hep G‐2 细胞周期，诱导细胞凋亡 (apoptosis)。

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Topoisomerase II inhibitor 9 Chemical Structure

Topoisomerase II inhibitor 9 Chemical Structure

CAS No. : 2413901-61-6

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Topoisomerase II inhibitor 9 相关抗体

Top Publications Citing Use of Products

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Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Topoisomerase II inhibitor 9 (Compound 19b) is a Topo II inhibitor with an IC50 of 0.97 μM. Topoisomerase II inhibitor 9 is also a classical DNA-intercalator with an IC50 of 43.51 μM. Topoisomerase II inhibitor 9 arrests the cell cycle at the G2/M phase and induces apoptosis in Hep G‐2 cells[1].

IC50 & Target

Topoisomerase II

0.97 μM (IC50)

体外研究
(In Vitro)

Topoisomerase II inhibitor 9 (Compound 19b) shows antiproliferative activity with IC50 values of 0.50 ± 0.1, 0.75 ± 0.1 and 2.91 ± 0.1 μM against Hep G‐2, Hep‐2 and Caco‐2 cells, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Topoisomerase II inhibitor 9 相关抗体:
分子量

491.55

Formula

C22H17N7O3S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Topoisomerase II inhibitor 9 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Topoisomerase II inhibitor 92413901-61-6Topoisomerase II inhibitor9Topoisomerase II inhibitor-9TopoisomeraseApoptosisHep G‐2Hep‐2Caco‐2anticancerBcl‐2BaxInhibitorinhibitorinhibit

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