2. Apoptosis
  3. MDM-2/p53 Apoptosis
  4. Triglycidyl isocyanurate

Triglycidyl isocyanurate  (Synonyms: TGIC)

目录号: HY-W011434 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

Triglycidyl isocyanurate (TGIC; Teroxirone) 是一种具有抗血管生成和抗肿瘤活性的三氮烯三环氧化合物。Triglycidyl isocyanurate 通过 p53 的激活抑制非小细胞肺癌细胞的生长。Triglycidyl isocyanurate 诱导细胞凋亡 (apoptosis)。Triglycidyl isocyanurate 可用于癌症研究。

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Triglycidyl isocyanurate Chemical Structure

Triglycidyl isocyanurate Chemical Structure

CAS No. : 2451-62-9

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Other Forms of Triglycidyl isocyanurate:

Triglycidyl isocyanurate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Triglycidyl isocyanurate (TGIC; Teroxirone) is a triazene triepoxide with antiangiogenic and antineoplastic activities. Triglycidyl isocyanurate inhibits the growth of non-small-cell-lung cancer cells via?p53 activation. Triglycidyl isocyanurate induces cell apoptosis. Triglycidyl isocyanurate can be used for cancer research[1][2].

体外研究
(In Vitro)

Triglycidyl isocyanurate?(0-30 μM; 48?hours) reduces the growth of spheroids of human non-small-cell-lung cancer cells in culture, it leads to a gradual reduction in size for tumorspheres of A549, H460 and H1299 cells[1].
Triglycidyl isocyanurate (0-30 μM; 48?hours) inhibits expression of akt1/2/3 and phosphorylated Aktser473/474/472?of A549, H460 and H1299 tumorspheres, however, the?cleavage?of PARP and?procaspase-3?plus the emergent active?caspase-3?fragment are only visible in H460 and A549 tumorspheres[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Triglycidyl isocyanurate 相关抗体:

Cell Viability Assay[1]

Cell Line: A549, H460 and H1299 cells
Concentration: 0 μM; 5 μM; 10 μM; 30 μM
Incubation Time: 48 hours
Result: Inhibited tumor cells growth in soft agar.

Western Blot Analysis[1]

Cell Line: A549, H460 and H1299 cells
Concentration: 0 μM; 5 μM; 10 μM; 30 μM
Incubation Time: 48 hours
Result: Inhibited akt1/2/3 expression and p-aktser473/474/472 expression of A549, H460 and H1299 tumorspheres
体内研究
(In Vivo)

Triglycidyl isocyanurate (subcutaneous injection; 1.8 and 3.6 mg/kg; every 2–3 days for total seven times; 30 days) suppresses the growth of xenograft tumors and has no effects on weight in nude mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female nu/nu mice with Huh7 cells subcutaneously injected into the dorsal area[2]
Dosage: 1.8 mg/kg and 3.6 mg/kg
Administration: Subcutaneous injection; every 2–3 days for total seven times; 30 days
Result: Inhibited the growth of xenograft tumors.
分子量

297.26

Formula

C12H15N3O6
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 50 mg/mL (168.20 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.3641 mL 16.8203 mL 33.6406 mL
5 mM 0.6728 mL 3.3641 mL 6.7281 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥98.0%

COA (197 KB) HNMR (289 KB)

产品使用指南 (1538 KB)
参考文献

Triglycidyl isocyanurate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3641 mL 16.8203 mL 33.6406 mL 84.1015 mL
5 mM 0.6728 mL 3.3641 mL 6.7281 mL 16.8203 mL
10 mM 0.3364 mL 1.6820 mL 3.3641 mL 8.4101 mL
15 mM 0.2243 mL 1.1214 mL 2.2427 mL 5.6068 mL
20 mM 0.1682 mL 0.8410 mL 1.6820 mL 4.2051 mL
25 mM 0.1346 mL 0.6728 mL 1.3456 mL 3.3641 mL
30 mM 0.1121 mL 0.5607 mL 1.1214 mL 2.8034 mL
40 mM 0.0841 mL 0.4205 mL 0.8410 mL 2.1025 mL
50 mM 0.0673 mL 0.3364 mL 0.6728 mL 1.6820 mL
60 mM 0.0561 mL 0.2803 mL 0.5607 mL 1.4017 mL
80 mM 0.0421 mL 0.2103 mL 0.4205 mL 1.0513 mL
100 mM 0.0336 mL 0.1682 mL 0.3364 mL 0.8410 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Triglycidyl isocyanurate2451-62-9TGICMDM-2/p53Apoptosisanticancer agentNSCLChepatocellularcarcinomaHCCtumorHepG2Hep3Bliver cancerInhibitorinhibitorinhibit

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