1. Protein Tyrosine Kinase/RTK Stem Cell/Wnt MAPK/ERK Pathway
  2. PDGFR ERK
  3. WQ-C-401

WQ-C-401 是一种具有口服活性的血小板衍生生长因子受体 (PDGFR) 抑制剂。WQ-C-401 通过浓度依赖的方式阻断 PDGFR 的自磷酸化来抑制细胞增殖,对 PDGFRα Y849 和 PDGFRβ Y1021 磷酸化的 EC50 值分别为 3.5 和 5.8 nM。同时,WQ-C-401 可以通过阻断 PDGF-BB 诱导的 ERK1/2 磷酸化,来抑制 PASMCs 增殖和迁移,减少胶原 I 合成并增加 α-SMA 表达,从而防止肺血管重塑。WQ-C-401 有望用于肺动脉高压领域的研究。

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WQ-C-401 Chemical Structure

WQ-C-401 Chemical Structure

CAS No. : 2376694-72-1

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

WQ-C-401 is an orally active platelet-derived growth factor receptor (PDGFR) inhibitor. WQ-C-401 inhibits cell proliferation by blocking PDGFR autophosphorylation in a concentration-dependent manner, with EC50 values of 3.5 nM for PDGFRα Y849 and 5.8 nM for PDGFRβ Y1021. Additionally, WQ-C-401 can inhibit PASMCs proliferation and migration by blocking PDGF-BB-induced ERK1/2 phosphorylation, reducing collagen I synthesis, and increasing α-SMA expression, thereby preventing pulmonary vascular remodeling. WQ-C-401 holds promise for research in the field of pulmonary arterial hypertension[1].

IC50 & Target

PDGFRβ

5.8 nM (EC50)

PDGFRα

3.5 nM (EC50)

分子量

418.49

Formula

C24H26N4O3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
WQ-C-401
目录号:
HY-162888
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