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  4. ZM600

ZM600 是一种有效和具有口服活性的抗肝纤维化剂。ZM600 可降低 collagen I、α-SM、p-p65 的蛋白表达。ZM600 具有用于肝纤维化研究的潜力。

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ZM600 Chemical Structure

ZM600 Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

ZM600 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ZM600 is a potent and orally active antihepatic fibrosis agent. ZM600 decreases the LPS (HY-D1056) induced protein expression of collagen I, α-SM, p-p65. ZM600 has the potential for the research of liver fibrosis[1].

体外研究
(In Vitro)

ZM600 对 LX-2 细胞有细胞毒性，IC50 值为 38.17 µM[1]。
ZM600 (0、5、10、20 µM；2+48 h) 可降低 LPS (HY-D1056) 和 TGF-β1 诱导的 collagen I 和 α-SM 的蛋白质和 mRNA 表达[1]。
ZM600 (0, 5, 10, 20 µM; 2+2 h) 可降低 LPS (HY-D1056) 和 TGF-β1 诱导的 LX-2 细胞中 p-p65、p-Smad2/3 和 p-AKT 的蛋白质表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ZM600 相关抗体:

RT-PCR[1]

Cell Line: LX-2 cells
Concentration: 0, 5, 10, 20 µM
Incubation Time: 2+48 h
Result: Suppressed LPS (1 µg/mL)-induced protein and mRNA expression of collagen I and α-SMA.

Western Blot Analysis[1]

Cell Line: LX-2 cells
Concentration: 0, 5, 10, 20 µM
Incubation Time: 2+2 h
Result: Decreased the LPS-induced protein expression of p-p65, inhibits TGF-β1-induced phosphorylation of Smad2/3 and AKT in a dose-dependent manner.
体内研究
(In Vivo)

ZM600 (15, 30 mg/kg; p.o.; daily for 3 weeks) 可减轻 CCl4 诱发的实验性肝纤维化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8 weeks, 18-20 g, Male C57BL/6J mice[1]
Dosage: 15, 30 mg/kg
Administration: P.o.; daly from the fifth week until 8 weeks
Result: Inhibited the infiltration of inflammatory cells and reduced the edema and necrosis of hepatocytes, decreased the deposition of collagens in liver tissues, decreased positive areas of α-SMA in the livers.
分子量

504.68

Formula

C33H41FO3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ZM600 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZM600ZM 600ZM-600Othersliver fibrosisLX-2 cellsp-p65p-Smad2/3p-AKTTGF-β1LPSorally activeInhibitorinhibitorinhibit

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产品名称：
ZM600
目录号：
HY-163778
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