Cetirizine (Synonyms: 西替利嗪)

目录号: HY-17042 纯度: 99.51%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

Cetirizine 是羟嗪的羧化代谢物，是第二代抗组胺药。Cetirizine 是一种特异的、口服有效的、H1 受体 的长效拮抗剂。Cetirizine 标记抗过敏特性，抑制过敏反应期间嗜酸性粒细胞趋化。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Cetirizine Chemical Structure

CAS No. : 83881-51-0

1. 客户无需承担相应的运输费用。

2. 同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

可免费申领三个不同产品的试用装。

3. 试用装只面向终端客户。

规格	价格	是否有货
10 mM * 1 mL in DMSO	￥275	In-stock
50 mg	￥250	In-stock
100 mg	￥400	In-stock
200 mg		询价
500 mg		询价

or 大包装询价

* Please select Quantity before adding items.

Other Forms of Cetirizine:

MCE 顾客使用本产品发表的 2 篇科研文献

IHC

: Cetirizine purchased from MCE. Usage Cited in: Pharmacol Res. 2017 Nov;125(Pt B):150-160. [Abstract]; The IL-33 production in different treatment groups is determined in rat skin by immunohistochemistry assay.

Cetirizine 相关产品

•相关化合物库:

•同靶点产品:

•同靶点蛋白产品:

查看 Histamine Receptor 亚型特异性产品:

查看所有亚型

H₁ Receptor H₂ Receptor H₃ Receptor H₄ Receptor Histamine Receptor

生物活性
纯度 & 产品资料
参考文献

生物活性

Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response^[1]^[2]^[3].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	> 30 μM Compound: 44, Cetirizine	Inhibition of human ERG potassium channel in HEK293 cells by patch clamp assay Inhibition of human ERG potassium channel in HEK293 cells by patch clamp assay	[PMID: 16931010]
HEK293	IC₅₀	> 500 μM Compound: cetirizine	Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay	[PMID: 23241029]
Huh-7	CC₅₀	> 100 μM Compound: Rac-3	Cytotoxicity against human Huh7.5.1 cells assessed as ATP level by luminescence analysis Cytotoxicity against human Huh7.5.1 cells assessed as ATP level by luminescence analysis	[PMID: 26599718]

体外研究
(In Vitro)

Cetirizine (>5 μM) at higher concentrations can reduce the release of GM-CSF and IL-8 from A549 cells stimulated with IL-1β. Cetirizine exerts anti-inflammatory effects beyond histamine H1-receptor antagonist^{[2]^.}

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	Human airway epithelial cell line A549.
Concentration:	0-10 μM.
Incubation Time:	24 h.
Result:	The survival of A549 cells incubated with various concentrations of cetirizine (0.1, 1, 2.5, 5, and 10 μM) for 24 hours were all higher than 90% when comparing with the control group by MTT test. Cetirizine, 5 and 10 μM, suppressed GM-CSF release by 70.71 and 61.55%, respectively. Preincubation with cetirizine, 10 μM, suppressed the IL-8 secretion by 75.04%.

体内研究
(In Vivo)

Cetirizine (20 mg/kg, mice, orally) exerts its anti-inflammatory effects by inhibiting MIF as well as IL-8 production in mice immunized and challenged with ragweed pollen^{[3]^.}

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male 8-week-old BALB/c mice (25-30 g) immunized and challenged with ragweed pollen^{[3]^.}
Dosage:	2 or 20 mg/kg.
Administration:	Orally, diluted in sterile water on days 18, 19, and 20.
Result:	The neutrophilia at 8 h and eosinophilia at 24 h induced by ragweed pollen extract per os were significantly reduced in the mice treated with 20 mg/kg. The dosage with 2 mg/kg had no effect.

Clinical Trial

分子量

388.89

Formula

C₂₁H₂₅ClN₂O₃

CAS 号

83881-51-0

性状

固体

颜色

Off-white to light yellow

中文名称

西替利嗪；西替利嗪

结构分类

Ketones, Aldehydes, Acids

初始来源

内源性代谢物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

细胞实验：

DMSO 中的溶解度 : 250 mg/mL (642.86 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.5714 mL	12.8571 mL	25.7142 mL
5 mM	0.5143 mL	2.5714 mL	5.1428 mL
10 mM	0.2571 mL	1.2857 mL	2.5714 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

以下溶解方案源自文献，仅供参考，建议您先取少量样品进行尝试。

方案一

Cetirizine is dissolved in PBS^[6].

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.51%

选择批次：

Data Sheet (604 KB) SDS (393 KB)

COA (282 KB) HNMR (268 KB) LCMS (87 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Caroline M. Spencer, et al. Cetirizine. Drugs 46 (6): 1055•1080, 1993.

[2]. Shih MY, et al. Influence of cetirizine and levocetirizine on two cytokines secretion in human airway epithelial cells. Allergy Asthma Proc. 2008 Sep-Oct;29(5):480-5. [Content Brief]

[3]. Shimizu T, et al. Cetirizine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor: its potential anti-inflammatory action. Clin Exp Allergy. 2004 Jan;34(1):103-9. [Content Brief]

Cetirizine 相关分类

Inflammation/Immunology Endocrinology

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5714 mL	12.8571 mL	25.7142 mL	64.2855 mL
	5 mM	0.5143 mL	2.5714 mL	5.1428 mL	12.8571 mL
	10 mM	0.2571 mL	1.2857 mL	2.5714 mL	6.4286 mL
	15 mM	0.1714 mL	0.8571 mL	1.7143 mL	4.2857 mL
	20 mM	0.1286 mL	0.6429 mL	1.2857 mL	3.2143 mL
	25 mM	0.1029 mL	0.5143 mL	1.0286 mL	2.5714 mL
	30 mM	0.0857 mL	0.4286 mL	0.8571 mL	2.1429 mL
	40 mM	0.0643 mL	0.3214 mL	0.6429 mL	1.6071 mL
	50 mM	0.0514 mL	0.2571 mL	0.5143 mL	1.2857 mL
	60 mM	0.0429 mL	0.2143 mL	0.4286 mL	1.0714 mL
	80 mM	0.0321 mL	0.1607 mL	0.3214 mL	0.8036 mL
	100 mM	0.0257 mL	0.1286 mL	0.2571 mL	0.6429 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cetirizine83881-51-0西替利嗪Histamine ReceptorhistamineSARARIL-1βGM-CSFIL-8SeasonalallergicrhinitisInhibitorinhibitorinhibit

您最近查看的产品:

产品名称：

* 需求量：

* 客户姓名：

* Email：

* 电话：

* 公司或机构名称：

留言给我们：

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Cetirizine (Synonyms: 西替利嗪)

Other Forms of Cetirizine:

MCE 顾客使用本产品发表的 2 篇科研文献