2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Indotecan

Indotecan  (Synonyms: LMP-400; NSC-724998)

目录号: HY-18351 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

Indotecan (LMP-400)，一种茚并异喹啉衍生物，是有效的拓扑异构酶 I 抑制剂。Indotecan 抑制 P388，HCT116，和 MCF-7 细胞系的 IC50 值分别为 300，1200，和 560 nM。Indotecan 抑制 DNA 超螺旋松弛，可用于内脏利什曼病的研究。

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Indotecan Chemical Structure

Indotecan Chemical Structure

CAS No. : 915303-09-2

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规格 价格 是否有货 数量
1 mg ￥720
In-stock
5 mg ￥1460
In-stock
10 mg ￥2350
In-stock
25 mg ￥4150
In-stock
50 mg ￥5980
In-stock
100 mg 现货 询价
200 mg   询价  
500 mg   询价  

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Customer Review

Other Forms of Indotecan:

Indotecan 相关抗体

Top Publications Citing Use of Products

查看 Topoisomerase 亚型特异性产品:

查看所有亚型
Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Indotecan (LMP-400), an indenoisoquinoline derivative, is a potent Topoisomerase I inhibitor, with IC50s of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. Indotecan prevents the relaxation of supercoiled DNA and can be used for the research of visceral leishmaniasis[1][2].

IC50 & Target[1]

Topoisomerase I

 

体外研究
(In Vitro)

Indotecan (48 h) 抑制 L. infantum 前鞭毛体、离体感染的脾细胞和未感染的脾细胞的 IC50 值分别为 0.10 μM，0.10 μM，和 57.16 μM[2]。
Indotecan (1.1-90 μM; 30 min) 诱导 TopI-DNA 共价配合物，并抑制 L. infantum 培养物中 DNA 合成[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Indotecan 相关抗体:
体内研究
(In Vivo)

Indotecan (2.5 mg/kg; 腹腔注射每 2 天一次共 15 天) 减轻了内脏利什曼病小鼠的脾脏和肝脏中的寄生负担[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice (4-6 weeks) were infected with metacyclic parasites intravenously through the tail vein[2]
Dosage: 2.5 mg/kg body weight per injection
Administration: Intraperitoneally every 2 days for 15 days (total, eight doses)
Result: A drastic reduction of the number of transforming amastigotes recovered from the target organs of drug-treated animals was observed.
Clinical Trial
分子量

478.49

Formula

C26H26N2O7
CAS 号
性状

固体

颜色

White to gray

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Indotecan 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Indotecan915303-09-2LMP-400 NSC-724998LMP400LMP 400NSC724998NSC 724998NSC-724998TopoisomeraseP388HCT116MCF-7upercoiled DNAvisceral leishmaniasisInhibitorinhibitorinhibit

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目录号：
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