Jervine  (Synonyms: 蒜黎芦碱; 11-Ketocyclopamine)

Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC₅₀ of 500-700 nM^[1]. Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum nigrum. Jervine has anti-inflammatory and antioxidant properties^[2].

IC50: 500-700 nM (Hedgehog)^[1]

Jervine (40 μM; 6, 12 and 24 hours) inhibits Akt phosphorylation^[3].
Jervine (40 μM; 2 hours) inhibits NF-jB activation decreased COX-2 overexpression and induced apoptosis^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Jervine (orally; 50-400 mg/kg) exerts 50.4-73.5% anti-inflammatory effects in carrageenan induced paw edema^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

425.60

C₂₇H₃₉NO₃

469-59-0

固体

White to off-white

蒜黎芦碱；介芬胺

Room temperature in continental US; may vary elsewhere.

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

• [1]. Williams JA, et al.Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basalcell carcinoma-like lesions.Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4616-21.  [Content Brief]

  [2]. Dumlu FA, et al.Anti-inflammatory and antioxidant properties of jervine, a sterodial alkaloid from rhizomes of Veratrum album.Phytomedicine. 2019 Mar 1;55:191-199.  [Content Brief]

  [3]. Ghezali L, et al.Cyclopamine and jervine induce COX-2 overexpression in human erythroleukemia cells but only cyclopamine has a pro-apoptotic effect.Exp Cell Res. 2013 Apr 15;319(7):1043-53.  [Content Brief]