1. GPCR/G Protein Metabolic Enzyme/Protease
  2. Oxytocin Receptor Endogenous Metabolite
  3. Oxytocin

Oxytocin  (Synonyms: 催产素; 缩宫素; α-Hypophamine; Oxytocic hormone)

目录号: HY-17571 纯度: 99.69%
COA 产品使用指南

Oxytocin (α-Hypophamine; Oxytocic hormone) 是一种多效的下丘脑肽 (hypothalamic peptide),有助于分娩、哺乳和亲社会行为。Oxytocin 可以作为一种压力应对分子,具有抗炎、抗氧化剂和保护作用,特别是在面对逆境或创伤时。

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Custom Peptide Synthesis

Oxytocin Chemical Structure

Oxytocin Chemical Structure

CAS No. : 50-56-6

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥1795
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2 mg ¥650
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5 mg ¥1150
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10 mg ¥1620
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25 mg ¥2430
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50 mg ¥3400
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100 mg ¥4760
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500 mg   询价  

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Customer Review

Other Forms of Oxytocin:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Oxytocin (α-Hypophamine; Oxytocic hormone) is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma[1][2].

IC50 & Target

Human Endogenous Metabolite

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO EC50
0.04 nM
Compound: 1; OT
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
[PMID: 27297999]
CHO EC50
10.8 nM
Compound: OT
Agonist activity at human oxytocin receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assay
Agonist activity at human oxytocin receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assay
[PMID: 21428295]
CHO EC50
24.5 nM
Compound: OT
Agonist activity at human vasopressin V1b receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assay
Agonist activity at human vasopressin V1b receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assay
[PMID: 21428295]
CHO-K1 EC50
2.3 nM
Compound: 1, OT
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
[PMID: 24874785]
COS-1 EC50
15 nM
Compound: 1, OT
Activity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assay
Activity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assay
[PMID: 21117646]
HEK293 IC50
> 10000 nM
Compound: 1, OT
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
[PMID: 24874785]
HEK293 EC50
0.0046 nM
Compound: OT
Agonist activity at human OTR receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
Agonist activity at human OTR receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
[PMID: 31229420]
HEK293 EC50
0.01 nM
Compound: OT
Agonist activity at recombinant human OTR expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
Agonist activity at recombinant human OTR expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
[PMID: 30896946]
HEK293 EC50
0.18 nM
Compound: OT
Agonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
Agonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
[PMID: 31229420]
HEK293 EC50
0.19 nM
Compound: OT
Agonist activity at recombinant human V1a receptor expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
Agonist activity at recombinant human V1a receptor expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
[PMID: 30896946]
HEK293 EC50
0.2 nM
Compound: OT
Agonist activity at human V1B receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
Agonist activity at human V1B receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
[PMID: 31229420]
HEK293 EC50
0.24 nM
Compound: OT
Agonist activity at recombinant human V1b receptor expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
Agonist activity at recombinant human V1b receptor expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
[PMID: 30896946]
HEK293 EC50
10 nM
Compound: 1, OT
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
[PMID: 24874785]
HEK293 EC50
2.1 nM
Compound: 1; OT
Agonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay
Agonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay
[PMID: 27420737]
HEK293 EC50
240 nM
Compound: 1, OT
Agonist activity at human vasopressin V1b expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
Agonist activity at human vasopressin V1b expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
[PMID: 24874785]
HEK293 EC50
5 nM
Compound: OT
Agonist activity at wild type OTR (unknown origin) expressed in HEK293 cells assessed as intracellular calcium flux after 3 mins by fluorescence assay
Agonist activity at wild type OTR (unknown origin) expressed in HEK293 cells assessed as intracellular calcium flux after 3 mins by fluorescence assay
[PMID: 25642985]
HEK293 EC50
7.3 nM
Compound: 1, OT
Agonist activity at human vasopressin V2 expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
Agonist activity at human vasopressin V2 expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
[PMID: 24874785]
HEK293 EC50
8 nM
Compound: OT
Agonist activity at SNAP-tagged oxytocin receptor (unknown origin) expressed in HEK293 cells assessed as intracellular calcium flux after 3 mins by fluorescence assay
Agonist activity at SNAP-tagged oxytocin receptor (unknown origin) expressed in HEK293 cells assessed as intracellular calcium flux after 3 mins by fluorescence assay
[PMID: 25642985]
体内研究
(In Vivo)

在 LMA 任务期间,大鼠核心体温略有下降。Oxytocin (皮下注射;0.1 mg/kg - 0.3 mg/kg;单剂量) 产生的低温效应 (0.3 mg/kg) 显著高于生理盐水或两种较低剂量的 Oxytocin 。0.3 mg/kg 的 Oxytocin 在注射后 15-60 分钟内产生的温度下降幅度显著高于载体,而 0.1 mg/kg 的 Oxytocin 仅在 30 分钟时间点略微降低温度[1]。与盐水对照组相比,Oxytocin (0.1 mg/kg)参与了显著更多的身体嗅探和肛门生殖器嗅探[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fifty-six male Lister-hooded rats (150-200 g)[1]
Dosage: 0.1 mg/kg-0.3 mg/kg
Administration: Subcutaneous injection; 0.1 mg/kg-0.3 mg/kg; single dose
Result: Produced significantly greater hypothermia (at 0.3 mg/kg) than the saline group.
分子量

1007.19

Formula

C43H66N12O12S2

CAS 号
性状

固体

颜色

White to off-white

Sequence

Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (Disulfide bridge:Cys1-Cys6)

Sequence Shortening

CYIQNCPLG-NH2 (Disulfide bridge:Cys1-Cys6)

中文名称

催产素;缩宫素

结构分类
初始来源

the paraventricular and supraoptic nuclei of the hypothalamus

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验: 

DMSO 中的溶解度 : 100 mg/mL (99.29 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.9929 mL 4.9643 mL 9.9286 mL
5 mM 0.1986 mL 0.9929 mL 1.9857 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.79%

参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9929 mL 4.9643 mL 9.9286 mL 24.8215 mL
5 mM 0.1986 mL 0.9929 mL 1.9857 mL 4.9643 mL
10 mM 0.0993 mL 0.4964 mL 0.9929 mL 2.4822 mL
15 mM 0.0662 mL 0.3310 mL 0.6619 mL 1.6548 mL
20 mM 0.0496 mL 0.2482 mL 0.4964 mL 1.2411 mL
25 mM 0.0397 mL 0.1986 mL 0.3971 mL 0.9929 mL
30 mM 0.0331 mL 0.1655 mL 0.3310 mL 0.8274 mL
40 mM 0.0248 mL 0.1241 mL 0.2482 mL 0.6205 mL
50 mM 0.0199 mL 0.0993 mL 0.1986 mL 0.4964 mL
60 mM 0.0165 mL 0.0827 mL 0.1655 mL 0.4137 mL
80 mM 0.0124 mL 0.0621 mL 0.1241 mL 0.3103 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Oxytocin
目录号:
HY-17571
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