2. Metabolic Enzyme/Protease Anti-infection
  3. Endogenous Metabolite Influenza Virus
  4. Spermine

Spermine  (Synonyms: 精胺; NSC 268508; Neuridine)

目录号: HY-B1777 纯度: 99.81%
COA 产品使用指南

摩尔计算器

Spermine (NSC 268508) 作为一个直接的自由基清除剂，能够保护 DNA 免受自由基的攻击。Spermine 具有抗病毒作用。

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Spermine Chemical Structure

Spermine Chemical Structure

CAS No. : 71-44-3

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
10 mM * 1 mL in Water ￥550
In-stock
100 mg ￥500
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Spermine:

Spermine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Spermine (NSC 268508) functions directly as a free radical scabenger to protect DNA from free radical attack. Spermine has antiviral effects.

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO IC50
> 100 μM
Compound: Spm, spermine
Cytotoxicity against CHO cells after 48 hrs by MTT assay
Cytotoxicity against CHO cells after 48 hrs by MTT assay
[PMID: 18558490]
CHO IC50
> 100 μM
Compound: Spm, spermine
Cytotoxicity against polyamine transport-deficient mutant CHO cells after 48 hrs by MTT assay
Cytotoxicity against polyamine transport-deficient mutant CHO cells after 48 hrs by MTT assay
[PMID: 18558490]
Fibroblast IC50
> 500 μM
Compound: Spermine
Cytotoxicity against human wild type CMS-24949 cells in presence of aminoguanidine measured after 72 hrs
Cytotoxicity against human wild type CMS-24949 cells in presence of aminoguanidine measured after 72 hrs
[PMID: 34695351]
Fibroblast IC50
> 500 μM
Compound: Spermine
Cytotoxicity against SMS mutant human CMS-23916 cells in presence of aminoguanidine measured after 72 hrs
Cytotoxicity against SMS mutant human CMS-23916 cells in presence of aminoguanidine measured after 72 hrs
[PMID: 34695351]
Fibroblast IC50
14.6 μM
Compound: Spermine
Cytotoxicity against SMS mutant human CMS-26559 cells in absence of aminoguanidine measured after 72 hrs
Cytotoxicity against SMS mutant human CMS-26559 cells in absence of aminoguanidine measured after 72 hrs
[PMID: 34695351]
Fibroblast IC50
14.9 μM
Compound: Spermine
Cytotoxicity against SMS mutant human CMS-23916 cells in absence of aminoguanidine measured after 72 hrs
Cytotoxicity against SMS mutant human CMS-23916 cells in absence of aminoguanidine measured after 72 hrs
[PMID: 34695351]
Fibroblast IC50
356.7 μM
Compound: Spermine
Cytotoxicity against SMS mutant human CMS-26559 cells in presence of aminoguanidine measured after 72 hrs
Cytotoxicity against SMS mutant human CMS-26559 cells in presence of aminoguanidine measured after 72 hrs
[PMID: 34695351]
Fibroblast IC50
422.1 μM
Compound: Spermine
Cytotoxicity against SMS mutant human CMS-6233 cells in presence of aminoguanidine measured after 72 hrs
Cytotoxicity against SMS mutant human CMS-6233 cells in presence of aminoguanidine measured after 72 hrs
[PMID: 34695351]
Huh-7 EC50
> 50 μM
Compound: Spermine
Antiviral activity against cell culture derived HCV expressing NS5A-GFP fusion protein infected in human HuH7 cells assessed as inhibition of viral life cycle after 72 hrs by Hoechst-33342 staining-based confocal microscopy
Antiviral activity against cell culture derived HCV expressing NS5A-GFP fusion protein infected in human HuH7 cells assessed as inhibition of viral life cycle after 72 hrs by Hoechst-33342 staining-based confocal microscopy
[PMID: 24177358]
L1210 IC50
54.5 μM
Compound: Spm, spermine
Cytotoxicity against mouse L1210 ATCC CCL 219 cells after 48 hrs by MTT assay
Cytotoxicity against mouse L1210 ATCC CCL 219 cells after 48 hrs by MTT assay
[PMID: 18558490]
体外研究
(In Vitro)

生理相关浓度的 Spermine (NSC 268508) 可抑制 ROS 诱导的 DNA 损伤，在 1 至 2 mM 时观察到最大抑制作用。这些浓度完全在 Spermine 生理浓度的估计范围内[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Spermine 相关抗体:
Clinical Trial
分子量

202.34

Formula

C10H26N4
CAS 号
性状

<28°C 固体,>30°C 液体

颜色

Colorless to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 125 mg/mL (617.77 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.9422 mL 24.7109 mL 49.4218 mL
5 mM 0.9884 mL 4.9422 mL 9.8844 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂： PBS

    Solubility: 100 mg/mL (494.22 mM); 澄清溶液; 超声助溶

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.81%

COA (276 KB) HNMR (238 KB) MS (68 KB) GC (178 KB)

产品使用指南 (1538 KB)
参考文献

Spermine 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.9422 mL 24.7109 mL 49.4218 mL 123.5544 mL
5 mM 0.9884 mL 4.9422 mL 9.8844 mL 24.7109 mL
10 mM 0.4942 mL 2.4711 mL 4.9422 mL 12.3554 mL
15 mM 0.3295 mL 1.6474 mL 3.2948 mL 8.2370 mL
20 mM 0.2471 mL 1.2355 mL 2.4711 mL 6.1777 mL
25 mM 0.1977 mL 0.9884 mL 1.9769 mL 4.9422 mL
30 mM 0.1647 mL 0.8237 mL 1.6474 mL 4.1185 mL
40 mM 0.1236 mL 0.6178 mL 1.2355 mL 3.0889 mL
50 mM 0.0988 mL 0.4942 mL 0.9884 mL 2.4711 mL
60 mM 0.0824 mL 0.4118 mL 0.8237 mL 2.0592 mL
80 mM 0.0618 mL 0.3089 mL 0.6178 mL 1.5444 mL
100 mM 0.0494 mL 0.2471 mL 0.4942 mL 1.2355 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Spermine71-44-3NSC 268508 NeuridineNSC268508NSC-268508Endogenous MetaboliteInfluenza VirusInhibitorinhibitorinhibit

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