2. Metabolic Enzyme/Protease Cytoskeleton Immunology/Inflammation
  3. MMP Collagen PD-1/PD-L1
  4. Anti-Human/Mouse denatured collagen type-I Antibody (XL313)

Anti-Human/Mouse denatured collagen type-I Antibody (XL313) 

目录号: HY-P990251 纯度: ≥95%
COA 技术支持

Anti-Human/Mouse denatured collagen type-I Antibody (XL313) 是一种源自小鼠的 IgG1 κ 型抗体抑制剂，靶向人/小鼠蛋白水解的 I 型胶原蛋白(denatured collagen type-I)。Anti-Human/Mouse denatured collagen type-I Antibody (XL313) 选择性结合蛋白水解的 I 型胶原蛋白。Anti-Human/Mouse denatured collagen type-I Antibody (XL313) 可降低肿瘤细胞中的 PD-L1 水平。Anti-Human/Mouse denatured collagen type-I Antibody (XL313) 可以用于癌症和炎症的研究，如卵巢肿瘤。

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Anti-Human/Mouse denatured collagen type-I Antibody (XL313)

Anti-Human/Mouse denatured collagen type-I Antibody (XL313) Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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1 mg ￥2100
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Anti-Human/Mouse denatured collagen type-I Antibody (XL313) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Human/Mouse denatured collagen type-I Antibody (XL313) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to human/mouse denatured collagen type-I. Anti-Human/Mouse denatured collagen type-I Antibody (XL313) selectively binds to proteolyzed collagen type I. Anti-Human/Mouse denatured collagen type-I Antibody (XL313) reduces PD L1 levels in tumor cells. Anti-Human/Mouse denatured collagen type-I Antibody (XL313) can be used for the researches of cancer and inflammation, such as such as ovarian tumor[1][2][3].

同型

Mouse IgG1 kappa
推荐同型对照抗体
反应种属

Human/Mouse
体外研究
(In Vitro)

Anti-Human/Mouse denatured collagen type-I Antibody (XL313) (16 h) 对蛋白水解的 I 型胶原蛋白具有结合选择性[1]。
Anti-Human/Mouse denatured collagen type-I Antibody (XL313) (10 μg, daily for 3 times) 显著抑制 FGF-2 诱导的出现炎症的鸡绒毛尿囊膜数量，并降低炎症浸润水平[1]。
Anti-Human/Mouse denatured collagen type-I Antibody (XL313) (10 μg/mL, 24 h) 对 B16F10 黑色素瘤细胞无细胞毒性[2]。
Anti-Human/Mouse denatured collagen type-I Antibody (XL313) (100 μg/mL, 15 mins or 1 h) 通过蛋白酶体依赖机制降低 B16F10、YUMM1.7、C32 和 A375 肿瘤细胞中的 PD L1 和细胞核 YAP 水平[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Human/Mouse denatured collagen type-I Antibody (XL313) 相关抗体:

Western Blot Analysis[2]

Cell Line: Β16F10, YUMM1.7, C32 and A375 tumor cells
Concentration: 100 μg/mL
Incubation Time: 15 min or 1 h
Result: Reduced PD L1 and nuclear YAP levels.
体内研究
(In Vivo)

Anti-Human/Mouse denatured collagen type-I Antibody (XL313) (250 μg，腹腔注射，每周 3 次，持续 14 或 21 天) 可抑制 B16F10/4T1 肿瘤模型小鼠的肿瘤生长[2]。
Anti-Human/Mouse denatured collagen type-I Antibody (XL313) (100 μg，腹腔注射，每周 1-2 次) 在腹腔内 ID8 肿瘤和 ID8-VEGF 卵巢肿瘤模型小鼠中显示出抗肿瘤作用[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Β16F10/4T1 tumor mice models[2]
Dosage: 250 μg
Administration: Intraperitoneally injection, 3 times a week for 14 or 21 days
Result: Inhibited tumor growth.
Animal Model: Intraperitoneal ID8 tumor mice models[3]
Dosage: 100 μg
Administration: Intraperitoneally injection, once per week for 7 weeks
Result: Showed a significant inhibition of approximately 80% in the tumor burden.
Reduced CD4+ T cells, F4/80 expressing macrophages and PDGFRa expressing cells in spleens.
Animal Model: ID8-VEGF ovarian tumor mice models[3]
Dosage: 100 μg
Administration: Intraperitoneally injection, twice per week
Result: Inhibited the growth of ID8-VEGF ovarian tumors.
Significantly inhibited the binding of the RGDKGE containing collagen fragment to ID8-VEGF cells.
Reduced abdominal distension and ascites volume.
Reduced levels of LAG-3 expressing cells.
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: ≥95%

COA (268 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Human/Mouse denatured collagen type-I Antibody (XL313) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Human/Mouse denatured collagen type-I Antibody (XL313)MMPCollagenPD-1/PD-L1Matrix metalloproteinasesPD-1/Programmed death-ligand 1Denatured collagen type-IPD-L1Ovarian tumorΒ16F10YUMM1.7C32A375Inhibitorinhibitorinhibit

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Anti-Human/Mouse denatured collagen type-I Antibody (XL313)
目录号：
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