2. Immunology/Inflammation Stem Cell/Wnt JAK/STAT Signaling Cytoskeleton NF-κB Metabolic Enzyme/Protease
  3. Transmembrane Glycoprotein STAT Collagen Reactive Oxygen Species (ROS) Interleukin Related
  4. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7)

Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) 

目录号: HY-P990294 纯度: 95.00%
COA 技术支持

Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) 是一种抗小鼠 CD106/VCAM-1 IgG1 单克隆抗体。Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) 通过降低 p-STAT3 和活性氧 (ROS) 水平来减少炎症反应和氧化应激。Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) 可以通过减少 I 型胶原 (collagen I) 和 III 型胶原 (collagen III) 的表达来缓解心脏炎症和纤维化。Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) 可用于研究心血管疾病如高血压心脏病和视网膜下纤维化。

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Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7)

Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) Chemical Structure

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Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) is an anti-mouse CD106/VCAM-1 IgG1 monoclonal antibody. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) reduces inflammatory response and oxidative stress by lowering p-STAT3 and reactive oxygen species (ROS) levels. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) can alleviate cardiac inflammation and fibrosis by reducing the expression of collagen I and collagen III. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) can be used for research on cardiovascular conditions such as hypertensive heart condition and subretinal fibrosis[1][2][3].

同型

Rat IgG1 kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target[3]

IL-1β

 

IL-6

 

p-STAT3

 

Collagen I

 

Collagen III

 

体外研究
(In Vitro)

Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) (25 μg/mL，4 小时) 可以显著抑制 VCAM-1 介导的单核细胞粘附，在 TNF-α 激活的小鼠心脏内皮细胞 (MCEC) 细胞中的抑制率为 52 %[1]。
Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) (20 μg/mL，10 小时) 可以阻断骨髓源性巨噬细胞 (BMDMs) 的迁移[2]。
Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) (5 μg/mL，10 小时) 显著抑制 Ang II 诱导的 BMDMs 粘附和迁移[3]。
Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) (5 μg/mL，24 小时) 通过减少巨噬细胞衍生的炎症因子来抑制心肌细胞肥大和成纤维细胞活化[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) 相关抗体:

Cell Migration Assay [2]

Cell Line: BMDMs
Concentration: 20 μg/mL
Incubation Time: 10 h
Result: Significantly reduced the number of macrophage migration caused by VCAM-1.

Cell Migration Assay [3]

Cell Line: BMDMs
Concentration: 5 μg/mL
Incubation Time: 10 h
Result: Significantly reduced the number of cell migrations caused by Ang II.

Western Blot Analysis[2]

Cell Line: Rat cardiomyocytes and cardiac fibroblasts
Concentration: 5 μg/mL
Incubation Time: 24 h
Result: Reduced the level of CaNA, p-STAT3, TGF-β1 and p-Smad2/3.

RT-PCR[2]

Cell Line: Rat cardiomyocytes and cardiac fibroblasts
Concentration: 5 μg/mL
Incubation Time: 24 h
Result: Reduced the level of ANF, BNP, collagen I and collagen III.
体内研究
(In Vivo)

Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) (6.85 μg/眼，玻璃体内注射，单次剂量，第二次激光后立即注射) 显著减少了激光诱导的视网膜下纤维化 C57BL/6J 小鼠的纤维化面积和巨噬细胞浸润[2]。
Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) (0.1 mg 或 0.2 mg，腹腔注射，每 2 天一次，持续 14 天) 剂量依赖性地改善 Ang II 诱导高血压心脏重塑的野生型雄性 C57BL/6J 小鼠心脏功能障碍，并减少心脏炎症和纤维化[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Laser induced C57BL/6J mice[2]
Dosage: 6.85 μg/eye
Administration: Intravitreal injection, single dose immediately after the second laser
Result: Significantly reduced the area of collagen-1 positive fibrosis.
Reduced F4/80+ macrophage infiltration.
Animal Model: Ang II (1,000 ng/kg/min, s.c., for 14 days) implanted wild-type male C57BL/6J mice[3]
Dosage: 0.1 mg or 0.2 mg
Administration: Intraperitoneal injection (i.p.), once every 2 days, for 14 days
Result: Improved the heart function decline caused by Ang II.
Reduced heart weight/body weight ratio and ANF/BNP/MYH7 mRNA expression.
Inhibited collagen deposition, collagen III, and α-SMA expression.
Reduced CD68+/VLA-4+ macrophage infiltration, IL-1β/IL-6/TNF-α mRNA expression, and ROS generation.
基因 ID

22329  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (268 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7)Transmembrane GlycoproteinSTATCollagenReactive Oxygen Species (ROS)Interleukin RelatedILCD106/VCAM-1STAT3ROScollagenfibrosisBMDMInhibitorinhibitorinhibit

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