2. Immunology/Inflammation Anti-infection
  3. Transmembrane Glycoprotein CHIKV
  4. Anti-Mouse Ly6C Antibody (Monts 1)

Anti-Mouse Ly6C Antibody (Monts 1) 

目录号: HY-P990200 纯度: 95.00%
COA 技术支持

Anti-Mouse Ly6C Antibody (Monts 1) 是一种源自大鼠的抗小鼠 Ly6C IgG2a 型抗体抑制剂。Anti-Mouse Ly6C Antibody (Monts 1) 可消耗单核细胞、中性粒细胞和其他一些粒细胞群。Anti-Mouse Ly6C Antibody (Monts 1) 可用于癌症、免疫学和感染等方面的研究，如基孔肯雅热 (CHIKV) 和侵袭性肿瘤。

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Anti-Mouse Ly6C Antibody (Monts 1)

Anti-Mouse Ly6C Antibody (Monts 1) Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥1800
In-stock
5 mg ￥6200
In-stock
10 mg ￥10000
In-stock
50 mg   询价  
100 mg   询价  

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Anti-Mouse Ly6C Antibody (Monts 1) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse Ly6C Antibody (Monts 1) is a rat-derived anti-mouse Ly6C IgG2a type antibody inhibitor. Anti-Mouse Ly6C Antibody (Monts 1) depletes monocytes, neutrophils, and some other granulocyte populations. Anti-Mouse Ly6C Antibody (Monts 1) can be used for the researches of cancer, immunology and infection, such as chikungunya (CHIKV) and aggressive tumor[1][2][3].

同型

Rat IgG2a kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

Ly6C
体外研究
(In Vitro)

抗体框架具有稳定性、特异性和适应性，同时具有结合抗原和内源免疫受体。 单克隆抗体具有几种衍生物，包括双特异性抗体、抗体-药物缀合物和抗体片段，在免疫学和肿瘤学等领域具有显著效果。 设计抑制性抗体时，需要注意包括抗原特异性可变区的鉴定、表达系统的选择、多特异性形式的使用以及基于片段化、寡聚化或与其他功能部分缀合的抗体衍生物[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse Ly6C Antibody (Monts 1) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse Ly6C Antibody (Monts 1) (200 μg，腹腔注射，每周一次，共 4 周) 可逆转侵袭性 KP 344SQ 肿瘤模型小鼠抗 PD-1/CTLA-4 免疫治疗的耐药性[1]。
Anti-Mouse Ly6C Antibody (Monts 1) (700 μg，腹腔注射，在感染前 24 小时给药一次) 减少基孔肯雅热模型小鼠皮肤中的基孔肯雅病毒感染以及随后的传播[2]。
Anti-Mouse Ly6C Antibody (Monts 1) (70 μg，结膜下给药，在感染前 7 天给药一次) 可清除单纯疱疹病毒 1 型诱导的亚临床角膜炎症中的巨噬细胞[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Aggressive KP 344SQ tumor mice models treated with PD-1/CTLA-4[1]
Dosage: 200 μg
Administration: Intraperitoneally injection, once a week for 4 weeks
Result: Reversed the resistance to anti-PD-1/CTLA-4 treatment.
Restored the levels of classical, non-classical monocytes and immune cell responses.
Animal Model: Mice were inoculated with chikungunya-LR in footpad[2]
Dosage: 700 μg
Administration: Intraperitoneally injection, 24 h prior to inoculation
Result: Reduced viral RNA levels.
Depleted monocytes, neutrophils, and some other granulocyte populations.
Significantly reduced in viral RNA levels in the skin, DLN, serum, spleen, and contralateral foot.
Animal Model: Mice with HSV-1(Herpes Simplex Virus-1)-induced subclinical corneal inflammation[3]
Dosage: 70 μg
Administration: Subconjuctivally administration, 7 days before infection
Result: Effectively depleted macrophages from HSV-1 infected.
基因 ID

17067  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (266 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse Ly6C Antibody (Monts 1) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse Ly6C Antibody (Monts 1)Transmembrane GlycoproteinCHIKVChikungunya virusLy6CMonocytesCancerImmunologyInfectionTumorInhibitorinhibitorinhibit

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