2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. BPIQ-I

BPIQ-I (PD 159121) 是一种有效的 ATP 竞争性 EGFR 酪氨酸激酶 (EGFR tyrosine kinase) 抑制剂。BPIQ-I 显示出积极的抗增殖作用。

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BPIQ-I Chemical Structure

BPIQ-I Chemical Structure

CAS No. : 174709-30-9

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规格 价格 是否有货 数量
500 μg ￥1966
3 - 4 周

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Customer Review

BPIQ-I 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BPIQ-I (PD 159121) is a potent and ATP-competitive EGFR tyrosine kinase inhibitor.. BPIQ-I shows anti-proliferative actively[1][2].

体外研究
(In Vitro)

BPIQ-I (0-50 µM; 3 days) 具有抗增殖活性，对 A-431, MDA-MB-468, U-87, SKOV-3, MDAMB-231 细胞的 EC50 值分别为 >50、30、>50、6.5、>50 µM [1].
BPIQ-I (10 nM) 通过与 ATP 竞争来阻断 erbB RTK，从而消除 CO2 敏感性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BPIQ-I 相关抗体:

Cell Viability Assay [1]

Cell Line: A-431, MDA-MB-468, U-87, SKOV-3, MDAMB-231 cells
Concentration: 0-50 µM
Incubation Time: 3 days
Result: Inhibited cells growth with EC50s of >50, 30, >50, 6.5, >50 µM for A-431, MDA-MB-468, U-87, SKOV-3, MDAMB-231 cells, respectively.
分子量

354.20

Formula

C16H12BrN5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BPIQ-I 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BPIQ-I174709-30-9PD 159121PD159121PD-159121EGFREpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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产品名称：
BPIQ-I
目录号：
HY-112405
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