2. Metabolic Enzyme/Protease Membrane Transporter/Ion Channel PI3K/Akt/mTOR
  3. Carbonic Anhydrase NKCC mTOR
  4. CAII/VII-IN-1

CAII/VII-IN-1 是一种口服活性的 hCA II (KI = 12.3 nM) 和 hCA VII (KI = 22.6 nM) 抑制剂，对 hCA I 没有表现出明显的活性。CAII/VII-IN-1 在体内Pilocarpine (HY-B0726A) 诱发的癫痫模型中表现出优异的神经保护活性。CAII/VII-IN-1 可以上调 KCC2 并抑制 mTOR，发挥神经保护作用。CAII/VII-IN-1 没有表现出任何明显的神经毒性作用或肝肾功能的改变。CAII/VII-IN-1 可用于癫痫的研究。

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CAII/VII-IN-1

CAII/VII-IN-1 Chemical Structure

CAS No. : 3085155-69-4

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CAII/VII-IN-1 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CAII/VII-IN-1 is an orally active hCA II (KI = 12.3 nM), and hCA VII (KI = 22.6 nM) inhibitor, showing no significant activity against hCA I. CAII/VII-IN-1 shows excellent neuroprotective activity in vivo Pilocarpine (HY-B0726A)-induced seizure model. CAII/VII-IN-1 can upregulate KCC2 and inhibit mTOR, exerting neuroprotective effects. CAII/VII-IN-1 does not show any significant neurotoxic effects or alterations in liver and kidney function. CAII/VII-IN-1 can be used for the study of epilepsy[1].

体外研究
(In Vitro)

CAII/VII-IN-1 (Compound 16d) 在 Vero 细胞中在给定浓度下是安全的 (IC50 = 59.7 μM)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CAII/VII-IN-1 相关抗体:
体内研究
(In Vivo)

CAII/VII-IN-1（200 mg/kg，口服，一次）在 Pilocarpine 诱导的小鼠中产生明显的抗惊厥和抗癫痫作用，表现为癫痫发作潜伏期增加两倍，癫痫发作严重程度显着降低，海马稳态恢复[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male mice (20-25 g) were injected with Pilocarpine[1].
Dosage: Orally before Pilocarpine injection.
Administration: Delayed seizures by more than twice as long as the Pilocarpine group (108.6 %).
Result: Delayed seizures by more than twice as long as the Pilocarpine group (108.6 %).
Showed comparable efficacy in delaying seizure onset and reducing severity at most time points.
Reached 100 % survival.
Upregulated KCC2 (188.1%) and inhibited mTOR (51.39%) exert neuroprotective effects.
分子量

639.11

Formula

C27H23ClN8O5S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CAII/VII-IN-1 相关分类

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Keywords:

CAII/VII-IN-13085155-69-4Carbonic AnhydraseNKCCmTORCarbonate dehydrataseNa-K-Cl cotransporterNa(+)-K(+)-Cl(-) cotransporterNa+-K+-Cl− cotransporter Mammalian target of RapamycinAnti-epilepticKCC2Neuroprotective activityPilocarpine-induced seizuresPrimary sulfonamides.Inhibitorinhibitorinhibit

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