2. Stem Cell/Wnt Apoptosis
  3. Hedgehog Smo Apoptosis
  4. CUR61414

CUR61414 是一种新型的可渗透细胞的 Hedgehog 信号通路抑制剂 (IC50 =100-200 nM)，CUR61414 是氨基脯氨酸类化合物的小分子成员，可选择性结合 Smoothened (Smo)，Ki  值为 44 nM。CUR-61414可以诱导癌细胞凋亡 (apoptosis) 而不会影响非癌症细胞。

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CUR61414 Chemical Structure

CUR61414 Chemical Structure

CAS No. : 334998-36-6

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规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥1696
In-stock
1 mg ￥596
In-stock
5 mg ￥1400
In-stock
10 mg ￥2300
In-stock
25 mg ￥4600
In-stock
50 mg 现货 询价
100 mg 现货 询价
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

CUR61414 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CUR61414 is a novel, potent and cell permeable Hedgehog signaling pathway inhibitor (IC50 =100-200 nM). CUR61414 is a small-molecule aminoproline class compound and selectively binds to smoothened (Smo) with a Ki  value of 44 nM. CUR-61414 can induce apoptosis in cancer cells without affecting neighboring non-tumor cells[1][2].

IC50 & Target

Hedgehog inhibitor[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
C3H 10T1/2 IC50
0.3 μM
Compound: Cur61414
Inhibition of N-terminal SHH activated pathway in mouse C3H10T1/2 cells assessed as SAG-induced cell differentiation by alkaline phosphatase assay
Inhibition of N-terminal SHH activated pathway in mouse C3H10T1/2 cells assessed as SAG-induced cell differentiation by alkaline phosphatase assay
[PMID: 21592788]
C3H 10T1/2 IC50
300 nM
Compound: Cur61414
Inhibition of SAG-induced differentiation of mouse mesenchymal pluripotent C3H10T1/2 cells to alkaline phosphatase positive oeseoblasts after 6 hrs
Inhibition of SAG-induced differentiation of mouse mesenchymal pluripotent C3H10T1/2 cells to alkaline phosphatase positive oeseoblasts after 6 hrs
[PMID: 22268551]
Shh Light II IC50
0.1 μM
Compound: Cur61414
Inhibition of SHH pathway in mouse Shh Light2 cells after 40 hrs by Gli-dependent luciferase reporter gene assay
Inhibition of SHH pathway in mouse Shh Light2 cells after 40 hrs by Gli-dependent luciferase reporter gene assay
[PMID: 21592788]
Shh Light II IC50
140 nM
Compound: Cur61414
Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assay
Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assay
[PMID: 22268551]
体外研究
(In Vitro)

CUR61414 is able to arrest proliferation of basal cells within the BCC-like lesions and induce cells to undergo apoptosis resulting in complete regression of the lesions, without affecting neighboring skin cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CUR61414 相关抗体:
体内研究
(In Vivo)

CUR61414 cause regression of these lesions in the mice, which are exposed to UV light irradiation for 6-9 months, producing many microscopic BCC-like basaloid lesions throughout their skin. Moreover,a significant increase in apoptotic nuclei can be seen in basaloid nests after CUR61414 treatment and no overt toxicity is observed in the skin surrounding the lesions[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

550.69

Formula

C31H42N4O5
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (181.59 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8159 mL 9.0795 mL 18.1590 mL
5 mM 0.3632 mL 1.8159 mL 3.6318 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.04%

COA (271 KB) HNMR (284 KB) LCMS (260 KB)

产品使用指南 (1538 KB)
参考文献

CUR61414 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8159 mL 9.0795 mL 18.1590 mL 45.3976 mL
5 mM 0.3632 mL 1.8159 mL 3.6318 mL 9.0795 mL
10 mM 0.1816 mL 0.9080 mL 1.8159 mL 4.5398 mL
15 mM 0.1211 mL 0.6053 mL 1.2106 mL 3.0265 mL
20 mM 0.0908 mL 0.4540 mL 0.9080 mL 2.2699 mL
25 mM 0.0726 mL 0.3632 mL 0.7264 mL 1.8159 mL
30 mM 0.0605 mL 0.3027 mL 0.6053 mL 1.5133 mL
40 mM 0.0454 mL 0.2270 mL 0.4540 mL 1.1349 mL
50 mM 0.0363 mL 0.1816 mL 0.3632 mL 0.9080 mL
60 mM 0.0303 mL 0.1513 mL 0.3027 mL 0.7566 mL
80 mM 0.0227 mL 0.1135 mL 0.2270 mL 0.5675 mL
100 mM 0.0182 mL 0.0908 mL 0.1816 mL 0.4540 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CUR61414334998-36-6CUR 61414CUR-61414HedgehogSmoApoptosisSmoothenedBCCbasal cell carcinoma,Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-113965
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